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Thiopurines: Factor...
Thiopurines: Factors influencing toxicity and response
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- Kambiz Fotoohi, Alan (author)
- Karolinska Institutet
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- Coulthard, Sally A (author)
- Linköpings universitet,Farmakologi,Hälsouniversitetet,Newcastle University
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- Albertioni, Freidoun (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: BIOCHEMICAL PHARMACOLOGY. - : Elsevier BV. - 0006-2952 .- 1873-2968. ; 79:9, s. 1211-1220
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Thiopurines are the backbone of current anti-leukemia regimens and have also been effective immunosuppressive agents for the past half a century. Extensive research on their mechanism of action has been undertaken, yet many issues remain to be addressed to resolve unexplained cases of thiopurine toxicity or treatment failure. The aim of this review is to summarize current knowledge of the mechanism of thiopurine action in experimental models and put into context with clinical observations. Clear understanding of their metabolism will contribute to maximizing efficacy and minimizing toxicity by individually tailoring therapy according to the expression profile of relevant factors involved in thiopurine activation pathway.
Keyword
- Acute lymphoblastic leukemia
- 6-Mercaptopurine
- 6-Thioguanine
- Azathioprine
- Hypoxanthine-guanine phosphoribosyl transferase
- Thiopurine methyltransferase
- Inosine 5 -monophosphate dehydrogenase
- Transport
- Pharmacogenetics
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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