onr:"swepub:oai:DiVA.org:liu-55055"
Search: onr:"swepub:oai:DiVA.org:liu-55055" > Expression and sign...
- 1 of 1
- Previous record
- Next record
- To hitlist
Expression and significance of FXYD-3 protein in gastric adenocarcinoma
-
- Zhu, Zhen-Long (author)
- Hebei Medical University
-
- Zhao, Zeng-Ren (author)
- Hebei Medical University
-
- Zhang, Yu (author)
- Hebei Medical University
- show more...
- show less...
- (creator_code:org_t)
- Ios Press, 2010
- 2010
- English.
- In: DISEASE MARKERS. - : Ios Press. - 0278-0240. ; 28:2, s. 63-69
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma. Patients and methods: FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n = 29) and gastric adenocarcinoma (n = 51), obtained from surgical resection of gastric cancer patients. Results: FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X-2=13.210, p andlt; 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X-2 = 5.765, p = 0.016). However, FXYD-3 expression was not correlated with patients gender, age, tumor size, lymph node status and histological grade (p andgt; 0.05). Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.
Keyword
- FXYD-3
- gastric cancer
- immunohistochemistry
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- DISEASE MARKERS (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Zhu, Zhen-Long
- Zhao, Zeng-Ren
- Zhang, Yu
- Yang, Yan-Hong
- Wang, Zheng-Min
- Cui, Dong-Sheng
- show more...
- Wang, Ming-Wei
- Kleeff, Joerg
- Kayed, Hany
- Yan, Bao-Yong
- Sun, Xiao-Feng
- show less...
- Articles in the publication
- DISEASE MARKERS
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
