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A global network of...
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
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- C. Lin, Yin (author)
- University of California San Diego
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- Jhunjhunwala, Suchit (author)
- University of California San Diego
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- Benner, Christopher (author)
- University of California San Diego
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- Heinz, Sven (author)
- University of California San Diego
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- Welinder, Eva (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California San Diego
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- Mansson, Robert (author)
- University of California San Diego
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- Sigvardsson, Mikael (author)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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- Hagman, James (author)
- National Jewish Health, Denver
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- A. Espinoza, Celso (author)
- University of California San Diego
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- Dutkowski, Janusz (author)
- University of California San Diego
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- Ideker, Trey (author)
- University of California San Diego
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- Glass, Christopher K. (author)
- University of California San Diego
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- Murre, Cornelis (author)
- University of California San Diego
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(creator_code:org_t)
- 2010-06-13
- 2010
- English.
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In: Nature Immunology. - : Nature Publishing Group. - 1529-2908 .- 1529-2916. ; 11:7, s. 635-U109
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Abstract
Subject headings
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- It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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C. Lin, Yin
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Jhunjhunwala, Su ...
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Benner, Christop ...
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Heinz, Sven
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Welinder, Eva
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Mansson, Robert
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show more...
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Sigvardsson, Mik ...
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Hagman, James
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A. Espinoza, Cel ...
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Dutkowski, Janus ...
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Ideker, Trey
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Glass, Christoph ...
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Murre, Cornelis
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Nature Immunolog ...
- By the university
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Linköping University
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Lund University