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Distribution of pro...
Distribution of prostaglandin EP3 and EP4 receptor mRNA in the rat parabrachial nucleus
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- Engblom, David (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Ek, Monica (author)
- Department of Medicine, Unit of Rheumatology, The Karolinska Institute, Stockholm, Sweden
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- Hallbeck, Martin (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Ericsson-Dahlstrand, Anders (author)
- Department of Medicine, Unit of Rheumatology, The Karolinska Institute, Stockholm, Sweden
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- Blomqvist, Anders (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam. 2000
- 2000
- English.
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In: Neuroscience Letters. - : Elsevier Science B.V., Amsterdam.. - 0304-3940 .- 1872-7972. ; 281:2-3, s. 163-166
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- By using in situ hybridization, the distribution of mRNA for the PGE2 receptors EP3 and EP4 was examined in the rat parabrachial nucleus (PB), a major brain stem relay for autonomic and nociceptive processing. EP3 receptor mRNA was present in most subnuclei, with the densest labeling in the external lateral, dorsal lateral, superior lateral, central lateral and Kölliker–Fuse nuclei. EP4 receptor mRNA expressing cells had a more restricted distribution, largely being confined to the superior lateral and adjacent parts of the dorsal and central lateral nuclei in a pattern complementary to that for EP3 receptor mRNA. These findings suggest that EP3 and EP4 receptors in PB have distinct functional roles that include nociceptive processing, blood pressure regulation and feeding behavior.
Keyword
- inflammation; pain; in situ hybridization; Kolliker-Fuse nucleus
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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