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Glutamate receptors...
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking
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- Engblom, David (author)
- German Cancer Research Center, Heidelberg
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- Bilbao, Ainhoa (author)
- Central Institute of Mental Health, Mannheim
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- Sanchis-Segura, Carles (author)
- Central Institute of Mental Health, Mannheim
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- Dahan, Lionel (author)
- University of Geneva
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- Perreau-Lenz, Stephanie (author)
- Central Institute of Mental Health, Mannheim
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- Balland, Benedicte (author)
- University of Geneva
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- Rodriguez Parkitna, Jan (author)
- German Cancer Research Center, Heidelberg
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- Lujan, Rafael (author)
- University of Castilla La Mancha
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- Halbout, Briac (author)
- Central Institute of Mental Health, Mannheim
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- Mameli, Manuel (author)
- University of Geneva
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- Parlato, Rosanna (author)
- German Cancer Research Center, Heidelberg
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- Sprengel, Rolf (author)
- Max Planck Institute
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- Luescher, Christian (author)
- University of Geneva
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- Schuetz, Guenther (author)
- German Cancer Research Center, Heidelberg
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- Spanagel, Rainer (author)
- Central Institute of Mental Health, Mannheim
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam. 2008
- 2008
- English.
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In: Neuron. - : Elsevier Science B.V., Amsterdam.. - 0896-6273 .- 1097-4199. ; 59:3, s. 497-508
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1-containing AMPA receptors. This cocaine-evoked plasticity depends on NMDA receptor activation, but its behavioral significance in the context of addiction remains elusive. Here, we generated mice lacking the GluR1, GluR2, or NR1 receptor subunits selectively in dopamine neurons. We report that in midbrain slices of cocaine-treated mice, synaptic transmission was no longer strengthened when GluR1 or NR1 was abolished, while in the respective mice the drug still induced normal conditioned place preference and locomotor sensitization. In contrast, extinction of drug-seeking behavior was absent in mice lacking GluR1, while in the NR1 mutant mice reinstatement was abolished. In conclusion, cocaine-evoked synaptic plasticity does not mediate concurrent short-term behavioral effects of the drug but may initiate adaptive changes eventually leading to the persistence of drug-seeking behavior.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neuron
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- By the author/editor
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Engblom, David
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Bilbao, Ainhoa
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Sanchis-Segura, ...
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Dahan, Lionel
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Perreau-Lenz, St ...
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Balland, Benedic ...
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Rodriguez Parkit ...
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Lujan, Rafael
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Halbout, Briac
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Mameli, Manuel
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Parlato, Rosanna
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Sprengel, Rolf
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Luescher, Christ ...
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Schuetz, Guenthe ...
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Spanagel, Rainer
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- Articles in the publication
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Neuron
- By the university
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Linköping University