Surface immobilized zoledronate improves screw fixation in rat bone: A new method for the coating of metal implants

Andersson, Therese (author): Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet

Agholme, Fredrik (author): Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet

Aspenberg, Per (author): Östergötlands Läns Landsting,Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet,Ortopedkliniken Linköping

Tengvall, Pentti (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials

(creator_code:org_t)

2010-09-21
2010
English.
In: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. - : Springer Science Business Media. - 0957-4530 .- 1573-4838. ; 21:11, s. 3029-3037

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Abstract Subject headings

Previous studies show that surface immobilized bisphosphonates improve the fixation of stainless steel screws in rat tibia after 2-8 weeks of implantation. We report here about the immobilization of a potent bisphosphonate, zoledronate, to crosslinked fibrinogen by the use of another technique, i.e. ethyl-dimethyl-aminopropylcarbodiimide (EDC)/imidazole immobilization. Bone fixation of zoledronate-coated screws was compared to screws coated with crosslinked fibrinogen only and ditto with EDC/N-hydroxy-succinimide immobilized pamidronate. Fixation in rat tibia was evaluated by a pull-out test at either 2 or 6 weeks after implantation. Both bisphosphonate coatings increased the pull-out force at both time points, and zoledronate showed a significantly higher pull-out force than pamidronate. To further evaluate the new coating technique we also performed a morphometric study, focusing on the area surrounding the implant. The zoledronate coating resulted in an increased bone density around the screws compared to controls. No pronounced increase was seen around the pamidronate coated screws. Together, the results demonstrate the possibility of obtaining a significant local therapeutic effect with minute amounts of surface immobilized zoledronate.

By the author/editor: Andersson, There ...; Agholme, Fredrik; Aspenberg, Per; Tengvall, Pentti

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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