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HIV-1 impairs in vi...
HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells
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- Che, Karlhans F (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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- Sabado, RL (author)
- New York University School of Medicine, New York, NY, USA
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- Shankar, Esaki M (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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- Tjomsland, Veronica (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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- Messmer, D (author)
- Moores Cancer Center, La Jolla, CA, USA
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- Bhardwa, N (author)
- New York University School of Medicine, New York, NY, USA
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- Lifson, JF (author)
- National Cancer Institute at Frederick, Maryland, MD, USA
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- Larsson, Marie (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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(creator_code:org_t)
- 2010-05-10
- 2010
- English.
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In: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 40:8, s. 2248-2258
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Abstract
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- Priming of T cells in lymphoid tissues of HIV-infected individuals occurs in the presence of HIV-1. DC in this milieu activate T cells and disseminate HIV-1 to newly activated T cells, the outcome of which may have serious implications in the development of optimal antiviral responses. We investigated the effects of HIV-1 on DC-naïve T-cell interactions using an allogeneic in vitro system. Our data demonstrate a dramatic decrease in the primary expansion of naïve T cells when cultured with HIV-1-exposed DC. CD4(+) and CD8(+) T cells showed enhanced expression of PD-1 and TRAIL, whereas CTLA-4 expression was observed on CD4(+) T cells. It is worth noting that T cells primed in the presence of HIV-1 suppressed priming of other naïve T cells in a contact-dependent manner. We identified PD-1, CTLA-4, and TRAIL pathways as responsible for this suppresion, as blocking these negative molecules restored T-cell proliferation to a higher degree. In conclusion, the presence of HIV-1 during DC priming produced cells with inhibitory effects on T-cell activation and proliferation, i.e. suppressor T cells, a mechanism that could contribute to the enhancement of HIV-1 pathogenesis.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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