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- Tulic, Meri KUniversity of Western Australia (author)
Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- Elsevier Science B.V., Amsterdam,2011
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-66292
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66292URI
- https://doi.org/10.1016/j.jaci.2010.09.020DOI
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- Language:English
- Summary in:English
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Notes
- Background: Microbial products are of central interest in the modulation of allergic propensity. Objective: We sought to explore whether allergic children show differences in microbial Toll-like receptor (TLR)-mediated responses over their first 5 years of life. Methods: Mononuclear cells isolated from 35 allergic and 35 nonallergic children at birth and 1, 2.5, and 5 years of age were stimulated with TLR2-TLR9 ligands to study innate immune function and with allergens or mitogen to assess adaptive T-cell responses. Cytokine production was measured by using Luminex multiplexing technology. Results: Nonallergic children show progressive and significant age-related increases in innate cytokine responses (IL-1 beta, IL-6, TNF-alpha, and IL-10) to virtually all TLR ligands. This innate maturation corresponds with a parallel increase in adaptive T(H)1 (IFN-gamma) responses to allergens and mitogens. In contrast, allergic children show exaggerated innate responses at birth (P andlt; .01) but a relative decrease with age thereafter, so that by age 5 years, TLR responses are attenuated compared with those seen in nonallergic subjects (P andlt; .05). This early hyperresponsiveness in allergic subjects fails to translate to a corresponding maturation of T(H)1 function, which remains attenuated relative to that seen in nonallergic subjects but is associated with a characteristic age-dependent increase in allergen-specific T(H)2 responses (P andlt; .01). Conclusion: Our findings suggest significant differences in the developmental trajectory of innate immune function in children with allergic disease that might contribute to the recognized differences in postnatal adaptive T-cell immunity.
Subject headings and genre
- Toll-like receptor
- ontogeny
- innate immunity
- allergic disease
- children
- TECHNOLOGY
- TEKNIKVETENSKAP
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- Hodder, MeganLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet (author)
- McCarthy, SuziUWA (author)
- A Thornton, CatherineSwansea University (author)
- Prescott, Susan LUniversity of Western Australia (author)
- University of Western AustraliaInstitutionen för klinisk och experimentell medicin (creator_code:org_t)
Related titles
- In:JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: Elsevier Science B.V., Amsterdam127:2, s. 470-U18170091-6749
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