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Surface-modified mi...
Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding
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Corrie, S R (author)
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Fernando, G J P (author)
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Crichton, M L (author)
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Brunck, M E G (author)
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- Anderson, Chris D (author)
- Östergötlands Läns Landsting,Linköpings universitet,Dermatologi och venerologi,Hälsouniversitetet,Hudkliniken i Östergötland
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Kendall, M A F (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Lab on a Chip. - 1473-0197 .- 1473-0189. ; 10, s. 2655-2658
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Minimally invasive biosensors are of great interest for rapid detection of disease biomarkers for diagnostic screening at the point-of-care. Here we introduce a device which extracts disease-specific biomarkers directly from the upper dermis, without the needle and syringe or resource-intensive blood processing. Using antigen-specific antibodies raised in mice as a model system, we confirm the analytical specificity and sensitivity of the antibody capture and extraction in comparison to the conventional methods based on needle/syringe blood draw followed by processing and antigen-specific ELISAs.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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