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  • Besser, Rachel E JUniversity of Exeter (author)

Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-02-17
  • American Diabetes Association Inc,2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-67027
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67027URI
  • https://doi.org/10.2337/dc10-2114DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE-Stimulated serum C-peptide (sCP) during a mixed-meal tolerance test (MMTT) is the gold standard measure of endogenous insulin secretion, but practical issues limit its use. We assessed urine C-peptide creatinine ratio (UCPCR) as an alternative. RESEARCH DESIGN AND METHODS-Seventy-two type 1 diabetic patients (age of diagnosis median 14 years [interquartile range 10-22]; diabetes duration 6.5[2.3-32.7]) had an MMTT. sCP was collected at 90 min. Urine for UCPCR was collected at 120 min and following a home evening meal. RESULTS-MMTT 120-min UCPCR was highly correlated to 90-min sCP (r = 0.97; P andlt; 0.0001). UCPCR andgt;= 0.53 nmol/mmol had 94% sensitivity/100% specificity for significant endogenous insulin secretion (90-min sCP andgt;= 0.2 nmol/L). The 120-min postprandial evening meal UCPCR was highly correlated to 90-min sCP (r = 0.91; P andlt; 0.0001). UCPCR andgt;= 0.37 nmol/mmol had 84% sensitivity/97% specificity for sCP andgt;= 0.2 nmol/L. CONCLUSIONS-UCPCR testing is a sensitive and specific method for detecting insulin secretion. UCPCR may be a practical alternative to serum C-peptide testing, avoiding the need for inpatient investigation.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (author)
  • Jones, Angus GUniversity of Exeter (author)
  • McDonald, Timothy JUniversity of Exeter (author)
  • Shields, Beverley MUniversity of Exeter (author)
  • Knight, Bridget AUniversity of Exeter (author)
  • Hattersley, Andrew TUniversity of Exeter (author)
  • University of ExeterPediatrik (creator_code:org_t)

Related titles

  • In:DIABETES CARE: American Diabetes Association Inc34:3, s. 607-6090149-59921935-5548

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