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Effects of simvasta...
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Nilsson, LennartÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken ViN
(author)
Effects of simvastatin on proinflammatory cytokines and matrix metalloproteinases in hypercholesterolemic individuals.
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2010-07-06
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Springer-Verlag New York,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-67141
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67141URI
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https://doi.org/10.1007/s10753-010-9227-yDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122890236URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Statins are potent lipid-lowering drugs but anti-inflammatory effects have also been suggested. Our aim was to investigate the effects of simvastatin on proinflammatory cytokines and matrix metalloproteinases (MMPs). Eighty hypercholesterolemic men were randomized to simvastatin 40 mg or placebo for 6 weeks. Simvastatin treatment significantly reduced C-reactive protein (CRP) levels while interleukin (IL)-6 levels remained unchanged. The ex vivo release of IL-1beta and IL-6 was not altered by simvastatin, whereas the release of TNF-alpha and IL-8 increased after 6 weeks of simvastatin treatment. Similarly, the circulating levels of MMP-3 and TIMP-1 remained unaffected by simvastatin while MMP-9 increased. However, none of the effects except for the CRP reduction within the simvastatin group reached statistical significance when compared to the placebo group. Our findings are in contrast to previous in vitro and animal data and question the in vivo relevance of some of the pleiotropic effects of simvastatin.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Eriksson, PerKarolinska Institutet
(author)
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Cherfan, PierreDepartment of Medicine, Högland Hospital, Eksjö
(author)
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Jonasson, LenaÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken US(Swepub:liu)lenjo59
(author)
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Linköpings universitetKardiologi
(creator_code:org_t)
Related titles
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In:Inflammation: Springer-Verlag New York34:4, s. 225-2300360-39971573-2576
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