Search: onr:"swepub:oai:DiVA.org:liu-67489" >
Myocardial perfusio...
Myocardial perfusion abnormalities by intravenous administration of the contrast agent NC100100 in an experimental model of coronary artery occlusion and reperfusion
-
- Rovai, Daniele (author)
- CNR, Institute of Clinical Physiology, Pisa, Italy
-
- Janerot-Sjöberg, Birgitta (author)
- Östergötlands Läns Landsting,Linköpings universitet,Fysiologisk mätteknik,Tekniska högskolan,Fysiologiska kliniken US
-
- Nagy, András (author)
- Gottsegen György Hungarian Institute of Cardiology, Budapest, Hungary
-
show more...
-
- Marini, Cecilia (author)
- CNR, Institute of Clinical Physiology, Pisa, Italy
-
- Burchielli, Silvia (author)
- CNR, Institute of Clinical Physiology, Pisa, Italy
-
- Castellari, Michele (author)
- CNR, Institute of Clinical Physiology, Pisa, Italy
-
- Morales, Maria-Aurora (author)
- CNR, Institute of Clinical Physiology, Pisa, Italy
-
- Trivella, M. Giovanna (author)
- CNR, Institute of Clinical Physiology, Pisa, Italy
-
- Ostensen, Jonny (author)
- Nycomed Imaging AS, Oslo, Norway
-
- Distante, Allessandro (author)
- University of Pisa, Pisa, Italy
-
- L'Abbate, Antonio (author)
- CNR, Institute of Clinical Physiology, Pisa, Italy
-
show less...
-
(creator_code:org_t)
- Wiley, 1998
- 1998
- English.
-
In: Echocardiography. - : Wiley. - 0742-2822 .- 1540-8175. ; 15:8, s. 731-740
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The aim of this study was to evaluate a second-generation echo contrast agent (NC100100) for the study of myocardial perfusion. In eight anesthetized open-chest dogs, this agent was injected intravenously under baseline conditions, during acute coronary thrombosis, and after reperfusion, using both fundamental (FI) and harmonic (HI) imaging, both continuous and intermittent imaging, and both ultrasound (US) and integrated backscatter (IBS) imaging. Contrast injections did not modify the hemodynamic parameters. With all imaging modalities, myocardial contrast enhancement (MCE) was higher with intermittent than with continuous imaging (134 vs 82 gray level/pixel using FI, P = 0.02; 62 vs 32 acoustic units using US HI, P = 0.02; and 52 vs 12 dB using IBS, P = 0.05). MCE equally increased using either US or IBS imaging. The accuracy of MCE in detecting perfusion defects during coronary occlusion and myocardial reperfusion after thrombolysis was very good (sensitivity and specificity = 93% and 95% and 89% and 93%, respectively). The extent of myocardial perfusion defects by echo contrast showed a closer correlation with microspheres using HI (r = 0.82) than FI (r = 0.53). Thus, the intravenous administration of NC100100 during intermittent HI allows myocardial perfusion abnormalities to be accurately detected during acute myocardial infarction.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Keyword
- Medical engineering
- Medicinsk teknik
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rovai, Daniele
-
Janerot-Sjöberg, ...
-
Nagy, András
-
Marini, Cecilia
-
Burchielli, Silv ...
-
Castellari, Mich ...
-
show more...
-
Morales, Maria-A ...
-
Trivella, M. Gio ...
-
Ostensen, Jonny
-
Distante, Alless ...
-
L'Abbate, Antoni ...
-
show less...
- About the subject
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Medical Engineer ...
-
and Medical Laborato ...
- Articles in the publication
-
Echocardiography
- By the university
-
Linköping University