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Wnt signaling and o...
Wnt signaling and orthopedics, an overview
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- Agholme, Fredrik (author)
- Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet
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- Aspenberg, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet,Ortopedkliniken i Linköping
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(creator_code:org_t)
- 2011-03-25
- 2011
- English.
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In: ACTA ORTHOPAEDICA. - : Informa Healthcare. - 1745-3674 .- 1745-3682. ; 82:2, s. 125-130
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Abstract
Subject headings
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- Wnt signaling is a ubiquitous system for intercellular communication, with multiple functions during development and in homeostasis of the body. It comprises several ligands, receptors, and inhibitors. Some molecules, such as sclerostin, appear to have bone-specific functions, and can be targeted by potential drugs. Now, ongoing clinical trials are testing these drugs as treatments for osteoporosis. Animal studies have also suggested that these drugs can accelerate fracture healing and implant fixation. This brief overview focuses on currently available information on the effects of manipulations of Wnt signaling on bone healing.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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