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Mustard seeds (Sina...
Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis
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- Yuan, Haifeng (author)
- Nanfang Hospital
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- Zhu, Minggu (author)
- Nanfang Hospital
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- Guo, Wen (author)
- Nanfang Hospital
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- Jin, Ling (author)
- Nanfang Hospital
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- Chen, Weihong (author)
- So Med University
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- Brunk, Ulf (author)
- Linköpings universitet,Farmakologi,Hälsouniversitetet
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- Zhao, Ming (author)
- So Med University
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(creator_code:org_t)
- MANEY PUBLISHING, STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND, 2011
- 2011
- English.
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In: REDOX REPORT. - : MANEY PUBLISHING, STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND. - 1351-0002. ; 16:1, s. 38-44
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mustard seeds (MS), which are consumed in considerable amounts by the Japanese people that, interestingly, have the longest life expectancy in the world, are known to contain a number of yet not fully defined but quite powerful anti-oxidants. A suspension of extracted MS was found to suppress oxidized-LDL-induced macrophage respiratory burst in vitro, to prevent growth, and to induce apoptotic death of SW480 cells (a human colon cancer cell line), while no such effects were found for normal 3T3 cells. A diet enriched with MS decreased plasma levels of the lipid peroxidation product malonaldehyde in mice exposed to the colon cancer-inducer azoxymethane (AOM). Such a diet also dose-dependently enhanced the activity of several anti-oxidant enzymes, such as superoxide dismutase (SOD), catalase, and GSH-peroxidase and, moreover, reduced AOM-mediated formation of colon adenomas by about 50%. Further studies are required to detail and explore the beneficial effects of MS and their rich content of powerful anti-oxidants.
Keyword
- Anti-oxidants
- Azoxymethane
- Colon cancer
- Mustard seeds
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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