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Swedish Two-County ...
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Tabar, LaszloFalun Central Hospital, Falun
(author)
Swedish Two-County Trial: Impact of Mammographic Screening on Breast Cancer Mortality during 3 Decades
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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Radiological Society of North America (RSNA),2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-70525
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70525URI
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https://doi.org/10.1148/radiol.11110469DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|American Cancer Society||
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Purpose: To estimate the long-term (29-year) effect of mammographic screening on breast cancer mortality in terms of both relative and absolute effects. less thanbrgreater than less thanbrgreater thanMaterials and Methods: This study was carried out under the auspices of the Swedish National Board of Health and Welfare. The board determined that, because randomization was at a community level and was to invitation to screening, informed verbal consent could be given by the participants when they attended the screening examination. A total of 133 065 women aged 40-74 years residing in two Swedish counties were randomized into a group invited to mammographic screening and a control group receiving usual care. Case status and cause of death were determined by the local trial end point committees and, independently, by an external committee. Mortality analysis was performed by using negative binomial regression. less thanbrgreater than less thanbrgreater thanResults: There was a highly significant reduction in breast cancer mortality in women invited to screening according to both local end point committee data (relative risk [RR] = 0.69; 95% confi dence interval: 0.56, 0.84; P andlt;.0001) and consensus data (RR = 0.73; 95% confi dence interval: 0.59, 0.89; P =.002). At 29 years of follow-up, the number of women needed to undergo screening for 7 years to prevent one breast cancer death was 414 according to local data and 519 according to consensus data. Most prevented breast cancer deaths would have occurred (in the absence of screening) after the first 10 years of follow-up. less thanbrgreater than less thanbrgreater thanConclusion: Invitation to mammographic screening results in a highly significant decrease in breast cancer-specific mortality. Evaluation of the full impact of screening, in particular estimates of absolute benefit and number needed to screen, requires follow-up times exceeding 20 years because the observed number of breast cancer deaths prevented increases with increasing time of follow-up.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Vitak, BedrichÖstergötlands Läns Landsting,Onkologiska kliniken US
(author)
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Hsiu-Hsi Chen, TonyNational Taiwan University,Taipei, Taiwan
(author)
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Ming-Fang Yen, AmyTaipei Medical University, Taipei, Taiwan
(author)
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Cohen, AndersFalun Central Hospital, Falun
(author)
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Tot, TiborFalun Central Hospital, Falun
(author)
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Yueh-Hsia Chiu, SherryChang Gung University, Taoyuan, Taiwan
(author)
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Li-Sheng Chen, SamTaipei Medical University, Taipei, Taiwan
(author)
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Ching-Yuan Fann, JeanKainan University, Taoyuan, Taiwan
(author)
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Rosell, JohanÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)johro19
(author)
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Fohlin, HelenaÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologiska kliniken US,Onkologi(Swepub:liu)helfo18
(author)
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Smith, Robert AAmerican Cancer Society, Atlanta, USA
(author)
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Duffy, Stephen WQueen Mary University of London, London, UK
(author)
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Falun Central Hospital, FalunOnkologiska kliniken US
(creator_code:org_t)
Related titles
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In:Radiology: Radiological Society of North America (RSNA)260:3, s. 658-6630033-84191527-1315
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Tabar, Laszlo
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Vitak, Bedrich
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Cohen, Anders
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Tot, Tibor
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Yueh-Hsia Chiu, ...
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Li-Sheng Chen, S ...
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Rosell, Johan
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