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Effects of moderate...
Effects of moderate red wine consumption on liver fat and blood lipids : a prospective randomized study
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- Kechagias, Stergios (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Zanjani, Sepehr (author)
- Linköpings universitet,Internmedicin,Hälsouniversitetet
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- Gjellan, Solveig (author)
- Linköpings universitet,Internmedicin,Hälsouniversitetet
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- Dahlqvist Leinhard, Olof (author)
- Linköpings universitet,Medicinsk radiofysik,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Kihlberg, Johan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Medicinsk radiologi,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Röntgenkliniken i Linköping
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- Smedby, Örjan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping
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- Johansson, Lars (author)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Kullberg, Joel (author)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Ahlström, Håkan (author)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Lindström, Torbjörn (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Nyström, Fredrik (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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(creator_code:org_t)
- 2011-05-23
- 2011
- English.
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In: Annals of Medicine. - : Informa Healthcare. - 0785-3890 .- 1365-2060. ; 43:7, s. 545-554
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Abstract
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- Background : There have been no human prospective randomized studies of the amount of alcohol that can induce hepatic steatosis. less thanbrgreater than less thanbrgreater thanMethods : Thirty-two healthy women and twelve healthy men (34 +/- 9 years of age) were randomized to consume 150 ml of red wine/day for women (16 g ethanol/day) or double that amount for men (33 g ethanol/day), or to alcohol abstention for 90 days. Participants underwent proton-nuclear magnetic-resonance spectroscopy for measurement of hepatic triglyceride content (HTGC). Blood samples for assessment of cardiovascular risk were drawn before and after the intervention. less thanbrgreater than less thanbrgreater thanResults: After exclusion of three subjects with steatosis at baseline a trend towards increased HTGC was apparent for red wine (before median: 1.1%, range 0.2-3.9%, after median: 1.1%, range 0.5-5.2%, P = 0.059) a difference that was statistically significant compared with abstainers (p = 0.02). However, no subject developed hepatic steatosis. Low-density lipoprotein (LDL)-cholesterol was lowered by red wine (-0.3 mmol/l, SE-0.1, 95% CI-0.6 to -0.04). less thanbrgreater than less thanbrgreater thanConclusions: Moderate consumption of red wine during three months increased HTGC in subjects without steatosis at baseline. However, since not a single participant developed steatosis we suggest that the threshold of alcohol consumption to define nonalcoholic fatty liver disease should not be lower than the amount in our study.
Keyword
- alcohol
- hepatic triglyceride content
- NAFLD
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kechagias, Sterg ...
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Zanjani, Sepehr
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Gjellan, Solveig
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Dahlqvist Leinha ...
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Kihlberg, Johan
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Smedby, Örjan
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show more...
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Johansson, Lars
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Kullberg, Joel
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Ahlström, Håkan
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Lindström, Torbj ...
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Nyström, Fredrik
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- Articles in the publication
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Annals of Medici ...
- By the university
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Linköping University
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Uppsala University