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  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine (author)

Hematopoietic Stem Cell Transplantation Rates and Long-Term Survival in Acute Myeloid and Lymphoblastic Leukemia Real-World Population-Based Data From the Swedish Acute Leukemia Registry 1997-2006

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-03-08
  • Philadelphia :Wiley-Blackwell,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-71382
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71382URI
  • https://doi.org/10.1002/cncr.26033DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41029URI
  • https://lup.lub.lu.se/record/1884166URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123268269URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160151URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Association of Local Authorities and Regions (SKL)||
  • Bengt Smedmyr, Institutionen för medicinska vetenskaper, medicin (Hematologi)
  • BACKGROUND: Allogeneic stem cell transplantation (alloSCT) reduces relapse rates in acute leukemia, but outcome is hampered by toxicity. Population-based data avoid patient selection and may therefore substitute for lack of randomized trials. METHODS: We evaluated alloSCT rates within the Swedish Acute Leukemia Registry, including 3899 adult patients diagnosed from 1997 through 2006 with a coverage of 98% and a median follow-up of 6.2 years. RESULTS: AlloSCT rates and survival decreased rapidly with age andgt;55 years. The 8-year overall survival (OS) was 65% in patients andlt;30 years and 38% in patients andlt;60 years and was similar for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Among 1073 patients andlt;60 years, alloSCT was performed in 42% and 49% of patients with AML and ALL, respectively. Two-thirds of the alloSCTs were performed in first complete remission, and half used unrelated donors, the same in AML and ALL. Regional differences in management and outcome were found: 60% of AML patients andlt;40 years received alloSCT in all parts of Sweden, but two-thirds of AML patients 40-59 years had alloSCT in one region compared with one-third in other regions (Pandlt;.001), with improved 8-year OS among all AML patients in this age cohort (51% vs 30%; P = .005). CONCLUSIONS: More Swedish AML patients received alloSCT, and long-term survival was better than in recently published large international studies, despite our lack of selection bias. There was no correlation between alloSCT rate and survival in ALL. In adult AML patients andlt;60 years of age, a high alloSCT rate was associated with better long-term survival, but there was no such correlation in ALL.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Karlsson, KarinLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)stem-kka (author)
  • Lazarevic, VladimirLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-lzv (author)
  • Wahlin, AndersUmeå universitet,Onkologi,Umeå University(Swepub:umu)anwa0027 (author)
  • Brune, MatsSahlgrens University Hospital (author)
  • Antunovic, PetarLinköpings universitet,Hälsouniversitetet,Kirurgi(Swepub:liu)petan27 (author)
  • Derolf, AsaKarolinska Institutet,Karolinska University Hospital (author)
  • Hägglund, HansUppsala universitet,Hematologi,Karolinska University Hospital(Swepub:uu)hanha689 (author)
  • Karbach, HolgerLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet(Swepub:liu)holka56 (author)
  • Lehmann, SorenKarolinska Institutet,Karolinska University Hospital (author)
  • Mollgard, LarsKarolinska Institutet,Karolinska University Hospital (author)
  • Stockelberg, DickSahlgrens University Hospital (author)
  • Hallböök, HeleneUppsala universitet,Medicin,Hematologi,Academic Hospital, Uppsala(Swepub:uu)helehall (author)
  • Höglund, MartinUppsala universitet,Medicin,Hematologi,Academic Hospital, Uppsala(Swepub:uu)martinhl (author)
  • Stamcellscentrum (SCC)Avdelningen för stamcellsforskning (creator_code:org_t)

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