A comparison of two methods for estimating refill adherence to statins in Sweden: the RARE project

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Lesén, Eva,1982Nordic School for Public Health (author)

A comparison of two methods for estimating refill adherence to statins in Sweden: the RARE project

Article/chapterEnglish2011

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2011-08-19
John Wiley and Sons,2011
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LIBRIS-ID:oai:DiVA.org:liu-71545
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71545URI
https://doi.org/10.1002/pds.2204DOI
https://gup.ub.gu.se/publication/146099URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Purpose To analyse and compare refill adherence to statins estimated with two different methods with a focus on sensitivity to definitions. less thanbrgreater than less thanbrgreater thanMethods Individuals aged 18-85 years who filled a statin prescription for the first time in 1.5 years during 1 January-30 June 2007 were followed until emigration or death or until 2 years after their first statin purchase. The data were collected via linkage between the Swedish Prescribed Drug Register, the National Patient Register and the Total Population Register. Days supply was estimated based on amount dispensed and prescribed dosage. Refill adherence was estimated with the continuous measure of medication acquisition (CMA) and the maximum gap method (cut-off 45days). The impact of altering definitions, for example, regarding hospitalisations, length of observation period and management of overlapping supply, was analysed. less thanbrgreater than less thanbrgreater thanResults The study included 36661 individuals (mean age 64 years, 47% women). The median proportion of days with statins was 95%, and 76% were classified as adherent with a cut-off at andgt;= 80% with CMA. With the maximum gap method, 65% were adherent. Disregarding hospitalisations did not alter the results. Emigration or death at least one year after statin initiation was associated with a lower adherence with both methods, and a shorter observation period and adding overlapping supply to the subsequent prescription increased the adherence estimates. less thanbrgreater than less thanbrgreater thanConclusions The choice of method and definitions, particularly regarding the management of overlapping supplies and the length of observation period, has a substantial impact on estimates of refill adherence to statins.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Samhällsfarmaci och klinisk farmaci hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Social and Clinical Pharmacy hsv//eng
medication adherence
drug utilisation
Swedish Prescribed Drug Register
statins
MEDICINE
MEDICIN
medication adherence; drug utilisation; Swedish Prescribed Drug Register; statins

Added entries (persons, corporate bodies, meetings, titles ...)

Sandstrom, Tatiana ZNordic School for Public Health (author)
Carlsten, Anders,1952Medical Prod Agency(Swepub:gu)xcaand (author)
Jönsson, Anna KÖstergötlands Läns Landsting,Linköpings universitet,Farmakologi,Hälsouniversitetet,Klinisk farmakologi (author)
Mårdby, Ann-Charlotte,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg(Swepub:gu)xmaann (author)
Andersson Sundell, Karolina,1978Nordic School for Public Health(Swepub:gu)xakarj (author)
Nordic School for Public HealthMedical Prod Agency (creator_code:org_t)

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In:Pharmacoepidemiology and Drug Safety: John Wiley and Sons20:10, s. 1073-10791053-85691099-1557

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By the author/editor: Lesén, Eva, 1982; Sandstrom, Tatia ...; Carlsten, Anders ...; Jönsson, Anna K; Mårdby, Ann-Char ...; Andersson Sundel ...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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