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NK Cell Function an...
NK Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller Patients
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- Johansson, Susanne E (author)
- Karolinska Institute
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- Rollman, Erik (author)
- University of Melbourne
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- Chung, Amy W (author)
- University of Melbourne
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- Center, Rob J (author)
- University of Melbourne
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- Hejdeman, Bo (author)
- Karolinska Institutet
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- Stratov, Ivan (author)
- University of Melbourne
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- Hinkula, Jorma (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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- Wahren, Britta (author)
- Karolinska Institutet
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- Kaerre, Klas (author)
- Karolinska Institutet
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- Kent, Stephen J (author)
- University of Melbourne
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- Berg, Louise (author)
- Karolinska Institutet
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(creator_code:org_t)
- Mary Ann Liebert, 2011
- 2011
- English.
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In: Viral immunology. - : Mary Ann Liebert. - 0882-8245 .- 1557-8976. ; 24:5, s. 359-368
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Abstract
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- Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the Fc gamma RIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC function and the presence of ADCC antibodies in plasma from 20 HIV-1-infected patients and 10 healthy donors. The HIV-positive patients were divided into two groups: six who controlled viremia for at least 8 y without treatment (controllers), and 14 who were persistently viremic and not currently on treatment. Plasma from both patient groups induced NK cell IFN-gamma expression and degranulation in response to HIV-1 envelope (Env) gp140-protein-coated cells. Patient antibodies mediating ADCC were largely directed towards the Env V3 loop, as identified by a gp140 protein lacking the V3 loop. Interestingly, in two controllers ADCC-mediating antibodies were more broadly directed to other parts of Env. A high viral load in patients correlated with decreased ADCC-mediated cytolysis of gp140-protein-coated target cells. NK cells from both infected patients and healthy donors degranulated efficiently in the presence of antibody-coated HIV-1-infected Jurkat cells. In conclusion, the character of ADCC-mediating antibodies differed in some controllers compared to viremic patients. NK cell ADCC activity is not compromised in HIV-infected patients.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Susan ...
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Rollman, Erik
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Chung, Amy W
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Center, Rob J
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Hejdeman, Bo
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Stratov, Ivan
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show more...
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Hinkula, Jorma
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Wahren, Britta
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Kaerre, Klas
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Kent, Stephen J
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Berg, Louise
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show less...
- Articles in the publication
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Viral immunology
- By the university
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Linköping University
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Karolinska Institutet