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NK Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller Patients
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- Johansson, Susanne E (author)
- Karolinska Institute
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- Rollman, Erik (author)
- University of Melbourne
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- Chung, Amy W (author)
- University of Melbourne
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- (creator_code:org_t)
- Mary Ann Liebert, 2011
- 2011
- English.
- In: Viral immunology. - : Mary Ann Liebert. - 0882-8245 .- 1557-8976. ; 24:5, s. 359-368
- Journal article (peer-reviewed)
Abstract
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- Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the Fc gamma RIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC function and the presence of ADCC antibodies in plasma from 20 HIV-1-infected patients and 10 healthy donors. The HIV-positive patients were divided into two groups: six who controlled viremia for at least 8 y without treatment (controllers), and 14 who were persistently viremic and not currently on treatment. Plasma from both patient groups induced NK cell IFN-gamma expression and degranulation in response to HIV-1 envelope (Env) gp140-protein-coated cells. Patient antibodies mediating ADCC were largely directed towards the Env V3 loop, as identified by a gp140 protein lacking the V3 loop. Interestingly, in two controllers ADCC-mediating antibodies were more broadly directed to other parts of Env. A high viral load in patients correlated with decreased ADCC-mediated cytolysis of gp140-protein-coated target cells. NK cells from both infected patients and healthy donors degranulated efficiently in the presence of antibody-coated HIV-1-infected Jurkat cells. In conclusion, the character of ADCC-mediating antibodies differed in some controllers compared to viremic patients. NK cell ADCC activity is not compromised in HIV-infected patients.
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- MEDICIN
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- Rollman, Erik
- Chung, Amy W
- Center, Rob J
- Hejdeman, Bo
- Stratov, Ivan
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- Hinkula, Jorma
- Wahren, Britta
- Kaerre, Klas
- Kent, Stephen J
- Berg, Louise
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- Linköping University
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