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Prognostic nomogram...
Prognostic nomogram to predict progression-free survival in patients with platinum-sensitive recurrent ovarian cancer
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- Lee, C.K. (author)
- University of Sydney
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- Simes, R.J. (author)
- University of Sydney
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- Brown, C. (author)
- University of Sydney
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- Lord, S. (author)
- University of Sydney
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- Wagner, U. (author)
- University Hospital Giessen and Marburg
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- Plante, M. (author)
- CHUQ Hotel Dieu Quebec
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- Vergote, I. (author)
- University Hospital Leuven
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- Pisano, C. (author)
- National Cancer Institute, Naples
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- Parma, G. (author)
- European Institute for Oncology
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- Burges, A. (author)
- Klinikum University of Munic
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- Bourgeois, H. (author)
- Centre Jean Bernard SARL SORECOH
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- Hogberg, T. (author)
- Östergötlands Läns Landsting,Onkologiska kliniken US
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- Bentley, J. (author)
- Dalhousie University, Halifax, NS B3H 1V7, Canada
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- Angleitner-Boubenizek, L. (author)
- BHS Linz, A-4020 Linz, Austria
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- Ferrero, A. (author)
- Mauriziano Hospital, Academic Div Gynecol Oncol, Turin, Italy
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- Richter, B. (author)
- University of Dresden, Department Gynecol and Obstet, Dresden, Germany
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- Hirte, H. (author)
- Juravinski Cancer Centre Hamilton Health Science, Hamilton, ON, Canada
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- Gebski, V. (author)
- University of Sydney, NHMRC Clin Trials Centre, Camperdown, NSW 1450, Australia
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- Pfisterer, J. (author)
- Staedt Klinikum Solingen, Department Gynecol, D-42653 Solingen, Germany
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- Pujade-Lauraine, E. (author)
- University of Paris 05, Hop University of Paris Centre, AP HP, F-75004 Paris, France
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- Friedlander, M. (author)
- Prince Wales Hospital, Institute Oncol, Sydney, NSW 2031, Australia
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(creator_code:org_t)
- 2011-09-13
- 2011
- English.
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In: British Journal of Cancer. - : Cancer Research UK. - 0007-0920 .- 1532-1827. ; 105:8, s. 1144-1150
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https://www.nature.c...
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Abstract
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- BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy. METHODS: The nomogram was developed in a training cohort (n = 955) from the CALYPSO trial and validated in the AGO-OVAR 2.5 Study (n = 340). The proportional-hazards model (nomogram) was based on pre-treatment characteristics. RESULTS: The nomogram had a concordance index (C-index) of 0.645. Significant predictors were tumour size platinum-chemotherapy-free interval, CA-125, number of organ metastatic sites and white blood count. When the nomogram was applied without CA-125 (CA-125 was not available in validation cohort), the C-indices were 0.624 (training) and 0.594 (validation). When classification was based only on the platinum-chemotherapy-free interval, the indices were 0.571 (training) and 0.560 (validation). The calibration plot in the validation cohort based on four predictors (without CA-125) suggested good agreement between actual and nomogram-predicted 12-month PFS probabilities. CONCLUSION: This nomogram, using five pre-treatment characteristics, improves prediction of PFS in patients with platinum-sensitive ovarian cancer having platinum-based chemotherapy. It will be useful for the design and stratification of patients in clinical trials and also for counselling patients.
Keyword
- nomogram; recurrent ovarian cancer; prognosis; platinum sensitivity; progression-free survival
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lee, C.K.
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Simes, R.J.
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Brown, C.
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Lord, S.
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Wagner, U.
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Plante, M.
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show more...
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Vergote, I.
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Pisano, C.
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Parma, G.
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Burges, A.
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Bourgeois, H.
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Hogberg, T.
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Bentley, J.
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Angleitner-Boube ...
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Ferrero, A.
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Richter, B.
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Hirte, H.
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Gebski, V.
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Pfisterer, J.
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Pujade-Lauraine, ...
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Friedlander, M.
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show less...
- Articles in the publication
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British Journal ...
- By the university
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Linköping University