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Up-regulation of sm...
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Lahdenperä, AnnaLinköpings universitet,Pediatrik,Hälsouniversitetet
(author)
Up-regulation of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-01-11
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John Wiley & Sons,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-74185
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-74185URI
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https://doi.org/10.1111/j.1365-2249.2011.04510.xDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Up-regulation of interleukin (IL)-17 in small intestinal mucosa has been reported in coeliac disease (CD) and in peripheral blood in type 1 diabetes (T1D). We explored mucosal IL-17 immunity in different stages of CD, including transglutaminase antibody (TGA)-positive children with potential CD, children with untreated and gluten-free diet-treated CD and in children with T1D. Immunohistochemistry was used for identification of IL-17 and forkhead box protein 3 (FoxP3)-positive cells and quantitative polymerase chain reaction (qPCR) for IL-17, FoxP3, retinoic acid-related orphan receptor (ROR)c and interferon (IFN)-γ transcripts. IL-1β, IL-6 and IL-17 were studied in supernatants from biopsy cultures. Expression of the apoptotic markers BAX and bcl-2 was evaluated in IL-17-stimulated CaCo-2 cells. The mucosal expression of IL-17 and FoxP3 transcripts were elevated in individuals with untreated CD when compared with the TGA-negative reference children, children with potential CD or gluten-free diet-treated children with CD (P andlt; 0·005 for all IL-17 comparisons and P andlt; 0·01 for all FoxP3 comparisons). The numbers of IL-17-positive cells were higher in lamina propria in children with CD than in children with T1D (P andlt; 0·05). In biopsy specimens from patients with untreated CD, enhanced spontaneous secretion of IL-1β, IL-6 and IL-17 was seen. Activation of anti-apoptotic bcl-2 in IL-17-treated CaCo-2 epithelial cells suggests that IL-17 might be involved in mucosal protection. Up-regulation of IL-17 could, however, serve as a biomarker for the development of villous atrophy and active CD.
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Hölttä, VNational Institute for Health and Welfare, Finland
(author)
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Ruohtula, TNational Institute for Health and Welfare, Finland
(author)
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Salo, H MNational Institute for Health and Welfare, Finland
(author)
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Orivuori, LNational Institute for Health and Welfare, Finland
(author)
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Westerholm-Ormio, MHospital for Children and Adolescents, University of Helsinki,
(author)
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Savilahti, EHospital for Children and Adolescents, University of Helsinki,
(author)
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Fälth-Magnusson, KarinÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)karfa12
(author)
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Högberg, LottaÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping(Swepub:liu)lotho28
(author)
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Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29
(author)
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Vaarala, ONational Institute for Health and Welfare, Finland
(author)
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Linköpings universitetPediatrik
(creator_code:org_t)
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In:Clinical and Experimental Immunology: John Wiley & Sons167:2, s. 226-2340009-91041365-2249
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Lahdenperä, Anna
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Hölttä, V
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Ruohtula, T
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Salo, H M
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Orivuori, L
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Westerholm-Ormio ...
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Savilahti, E
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Fälth-Magnusson, ...
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Högberg, Lotta
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Vaarala, O
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Linköping University