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  • Lahdenperä, AnnaLinköpings universitet,Pediatrik,Hälsouniversitetet (author)

Up-regulation of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012-01-11
  • John Wiley & Sons,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-74185
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-74185URI
  • https://doi.org/10.1111/j.1365-2249.2011.04510.xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Up-regulation of interleukin (IL)-17 in small intestinal mucosa has been reported in coeliac disease (CD) and in peripheral blood in type 1 diabetes (T1D). We explored mucosal IL-17 immunity in different stages of CD, including transglutaminase antibody (TGA)-positive children with potential CD, children with untreated and gluten-free diet-treated CD and in children with T1D. Immunohistochemistry was used for identification of IL-17 and forkhead box protein 3 (FoxP3)-positive cells and quantitative polymerase chain reaction (qPCR) for IL-17, FoxP3, retinoic acid-related orphan receptor (ROR)c and interferon (IFN)-γ transcripts. IL-1β, IL-6 and IL-17 were studied in supernatants from biopsy cultures. Expression of the apoptotic markers BAX and bcl-2 was evaluated in IL-17-stimulated CaCo-2 cells. The mucosal expression of IL-17 and FoxP3 transcripts were elevated in individuals with untreated CD when compared with the TGA-negative reference children, children with potential CD or gluten-free diet-treated children with CD (P andlt; 0·005 for all IL-17 comparisons and P andlt; 0·01 for all FoxP3 comparisons). The numbers of IL-17-positive cells were higher in lamina propria in children with CD than in children with T1D (P andlt; 0·05). In biopsy specimens from patients with untreated CD, enhanced spontaneous secretion of IL-1β, IL-6 and IL-17 was seen. Activation of anti-apoptotic bcl-2 in IL-17-treated CaCo-2 epithelial cells suggests that IL-17 might be involved in mucosal protection. Up-regulation of IL-17 could, however, serve as a biomarker for the development of villous atrophy and active CD.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hölttä, VNational Institute for Health and Welfare, Finland (author)
  • Ruohtula, TNational Institute for Health and Welfare, Finland (author)
  • Salo, H MNational Institute for Health and Welfare, Finland (author)
  • Orivuori, LNational Institute for Health and Welfare, Finland (author)
  • Westerholm-Ormio, MHospital for Children and Adolescents, University of Helsinki, (author)
  • Savilahti, EHospital for Children and Adolescents, University of Helsinki, (author)
  • Fälth-Magnusson, KarinÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)karfa12 (author)
  • Högberg, LottaÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping(Swepub:liu)lotho28 (author)
  • Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (author)
  • Vaarala, ONational Institute for Health and Welfare, Finland (author)
  • Linköpings universitetPediatrik (creator_code:org_t)

Related titles

  • In:Clinical and Experimental Immunology: John Wiley & Sons167:2, s. 226-2340009-91041365-2249

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