onr:"swepub:oai:DiVA.org:liu-75112"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04848naa a2200529 4500 | |
| 001 | oai:DiVA.org:liu-75112 | |
| 003 | SwePub | |
| 008 | 120217s2012 | |||||||||||000 ||eng| | |
| 009 | oai:gup.ub.gu.se/151554 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-751122 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1398-9995.2011.02707.x2 DOI |
| 024 | 7 | a https://gup.ub.gu.se/publication/1515542 URI |
| 040 | a (SwePub)liud (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bruhn, Sörenu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Genepathway, Inc., San Diego, CA, USA4 aut0 (Swepub:liu)sorbr27 |
| 245 | 1 0 | a Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis |
| 264 | c 2011-09-15 | |
| 264 | 1 | b John Wiley and Sons,c 2012 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agencies|European Commission|223367|MultiMod||Swedish Medical Research Council||US National Institutes of Health|P01-DA-015027-01R01-MH-074460-01U01-AA-013512U01-AA-013641-04|US Department of Energy under the EPSCoR Laboratory|| | |
| 520 | a Background: The transcription factor (TF) IRF4 is involved in the regulation of Th1, Th2, Th9, and Th17 cells, and animal studies have indicated an important role in allergy. However, IRF4 and its target genes have not been examined in human allergy. Methods: IRF4 and its target genes were examined in allergen-challenged CD4+ cells from patients with IAR, using combined gene expression microarrays and chromatin immunoprecipitation chips (ChIP-chips), computational target prediction, and RNAi knockdowns. Results: IRF4 increased in allergen-challenged CD4+ cells from patients with IAR, and functional studies supported its role in Th2 cell activation. IRF4 ChIP-chip showed that IRF4 regulated a large number of genes relevant to Th cell differentiation. However, neither Th1 nor Th2 cytokines were the direct targets of IRF4. To examine whether IRF4 induced Th2 cytokines via one or more downstream TFs, we combined gene expression microarrays, ChIP-chips, and computational target prediction and found a putative intermediary TF, namely ETS1 in allergen-challenged CD4+ cells from allergic patients. ETS1 increased significantly in allergen-challenged CD4+ cells from patients compared to controls. Gene expression microarrays before and after ETS1 RNAi knockdown showed that ETS1 induced Th2 cytokines as well as disease-related pathways. Conclusions: Increased expression of IRF4 in allergen-challenged CD4+ cells from patients with intermittent allergic rhinitis leads to activation of a complex transcriptional program, including Th2 cytokines. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
| 653 | a Allergy | |
| 653 | a transcription factor | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Barrenäs, Fredriku Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut0 (Swepub:gu)xbarfr |
| 700 | 1 | a Mobini, Reza,d 1965u Östergötlands Läns Landsting4 aut0 (Swepub:gu)xmobre |
| 700 | 1 | a Andersson, Bengt A.,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xabeng |
| 700 | 1 | a Chavali, Sreenivasu MRC Lab Molecular Biol, Cambridge, UK4 aut0 (Swepub:gu)xchasr |
| 700 | 1 | a Egan, B. S.u Genepathway, Inc., San Diego, CA, USA4 aut |
| 700 | 1 | a Hovig, E.u Norwegian Radium Hospital4 aut |
| 700 | 1 | a Sandve, G. K.u University of Oslo4 aut |
| 700 | 1 | a Langston, M. A.u University of Tennessee, Knoxville, TN, USA4 aut |
| 700 | 1 | a Rogers, G.u University of Tennessee, Knoxville, TN, USA4 aut |
| 700 | 1 | a Wang, Huiu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut0 (Swepub:liu)huiwa84 |
| 700 | 1 | a Benson, Mikaelu Linköpings universitet,Hälsouniversitetet,Pediatrik4 aut0 (Swepub:gu)xbenmi |
| 710 | 2 | a Linköpings universitetb Institutionen för klinisk och experimentell medicin4 org |
| 773 | 0 | t Allergy. European Journal of Allergy and Clinical Immunologyd : John Wiley and Sonsg 67:1, s. 33-40q 67:1<33-40x 0105-4538x 1398-9995 |
| 856 | 4 | u https://europepmc.org/articles/pmc3237963?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75112 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1398-9995.2011.02707.x |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/151554 |
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