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Preparation of amyloidlike fibrils containing magnetic iron oxide nanoparticles: Effect of protein aggregation on proton relaxivity
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- Andersson, Viktor (author)
- Linköpings universitet,Biomolekylär och Organisk Elektronik,Tekniska högskolan
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- Skoglund, Caroline (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska högskolan
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- Uvdal, Kajsa (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- (creator_code:org_t)
- Elsevier, 2012
- 2012
- English.
- In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier. - 0006-291X .- 1090-2104. ; 419:4, s. 682-686
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid material is heated in aqueous acid, the insulin/nanoparticle hybrid material self assembles to form amyloid-like fibrils incorporating the magnetic nanoparticles. This results in magnetically labeled amyloid-like fibrils which has been characterized by Transmission Electron Microscopy (TEM) and electron tomography. The influence of the aggregation process on proton relaxivity is investigated. The prepared materials have potential uses in a range of bio-imaging applications.
Keyword
- Amyloid fibrils
- Magnetic nanoparticles
- Electron tomography
- Self-assembly
- Proton relaxation
- TECHNOLOGY
- TEKNIKVETENSKAP
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- ref (subject category)
- art (subject category)
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