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A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants

Abtahi, Jahan (author)
Östergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Käkkliniken US
Tengvall, Pentti (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
Aspenberg, Per (author)
Linköpings universitet,Östergötlands Läns Landsting,Ortopedkliniken i Linköping,Ortopedi,Hälsouniversitetet
 (creator_code:org_t)
Elsevier, 2012
2012
English.
In: Bone. - : Elsevier. - 8756-3282 .- 1873-2763. ; 50:5, s. 1148-1151
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. The other implant was untreated. Fixation was evaluated by measurement of resonance frequency (implant stability quotient; ISQ) serving as a proxy for stiffness of the implant-bone construct. Increase in ISQ at 6 months of follow-up was the primary variable. None of the patients had any complications. The resonance frequency increased 6.9 ISQ units more for the coated implants (p = 0.0001; Cohens d = 1.3). The average difference in increase in ISQ and the effect size, suggested a clinically relevant improvement. X-ray showed less bone resorption at the margin of the implant both at 2 months (p = 0.012) and at 6 months (p = 0.012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

Keyword

Bone healing
Dental implant
Drug delivery
Mechanical test
Osseointegration bisphosphonates
MEDICINE
MEDICIN

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art (subject category)

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By the author/editor
Abtahi, Jahan
Tengvall, Pentti
Aspenberg, Per
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Medical Biotechn ...
and Biomaterials Sci ...
Articles in the publication
Bone
By the university
Linköping University
University of Gothenburg

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