A Human Vascular Model Based on Microdialysis for the Assessment of the Vasoconstrictive Dose-Response Effects of Norepinephrine and Vasopressin in Skin

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Tchou Folkesson, KimLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet (author)

A Human Vascular Model Based on Microdialysis for the Assessment of the Vasoconstrictive Dose-Response Effects of Norepinephrine and Vasopressin in Skin

Article/chapterEnglish2012

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2012-04-24
Informa Healthcare / John Wiley and Sons,2012
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LIBRIS-ID:oai:DiVA.org:liu-77530
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77530URI
https://doi.org/10.1111/j.1549-8719.2012.00170.xDOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding Agencies|Berzelius Clinical Research Center AB, Linkoping, Sweden||
Abstract Objective: Microdialysis enables drug delivery in the skin and simultaneous measurement of their effects. The present study aimed to evaluate dose-dependent changes in blood flow and metabolism during microdialysis of norepinephrine and vasopressin. Methods: We investigated whether increasing concentrations of norepinephrine (NE, 1.859 mu mol/L) and vasopressin (VP, 1100 nmol/L), delivered sequentially in one catheter or simultaneously through four catheters, yield dose-dependent changes in blood flow (as measured using urea clearance) and metabolism (glucose and lactate). Results: We found a significant dose-dependent vasoconstriction with both drugs. Responses were characterized by a sigmoid dose response model. Urea in the dialysate increased from a baseline of 7.9 +/- 1.7 to 10.9 +/- 0.9 mmol/L for the highest concentration of NE (p andlt; 0.001) and from 8.1 +/- 1.4 to 10.0 +/- 1.7 mmol/L for the highest concentration of VP (p = 0.037). Glucose decreased from 2.3 +/- 0.7 to 0.41 +/- 0.18 mmol/L for NE (p = 0.001) and from 2.7 +/- 0.6 to 1.3 +/- 0.5 mmol/L for VP (p andlt; 0.001). Lactate increased from 1.1 +/- 0.4 to 2.6 +/- 0.5 mmol/L for NE (p = 0.005) and from 1.1 +/- 0.4 to 2.6 +/- 0.5 mmol/L for VP (p = 0.008). There were no significant differences between responses from a single catheter and from those obtained simultaneously using multiple catheters. Conclusions: Microdialysis in the skin, either with a single catheter or using multiple catheters, offers a useful tool for studying dose response effects of vasoactive drugs on local blood flow and metabolism without inducing any systemic effects.

Subject headings and genre

microdialysis
urea
skin
noradrenalin
vasopressin
dose-response
pharmacodynamics
human
vasoconstriction
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Samuelsson, AndersÖstergötlands Läns Landsting,Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet,Intensivvårdskliniken US(Swepub:liu)andsa70 (author)
Tesselaar, ErikLinköpings universitet,Brännskadevård,Hälsouniversitetet(Swepub:liu)eridr03 (author)
Dahlström, BengtAB Biopharmacon, Uppsala (author)
Sjöberg, FolkeÖstergötlands Läns Landsting,Linköpings universitet,Brännskadevård,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US,Anestesi- och operationkliniken US(Swepub:liu)folsj94 (author)
Linköpings universitetInstitutionen för klinisk och experimentell medicin (creator_code:org_t)

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In:Microcirculation: Informa Healthcare / John Wiley and Sons19:4, s. 352-3591073-96881549-8719

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