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Two-dimensional gel...
Two-dimensional gel electrophoresis and mass spectrometry in studies of nanoparticle-protein interactions
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- Karlsson, Helen, 1961- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Arbets- och miljövetenskap,Hälsouniversitetet,Arbets- och miljömedicin
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- Ljunggren, Stefan (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Ahrén, Maria (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Ghafouri, Bijar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Rehabiliteringsmedicin,Hälsouniversitetet,Smärt och rehabiliteringscentrum
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- Uvdal, Kajsa (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Lindahl, Mats (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Ljungman, Anders (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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(creator_code:org_t)
- 2012-04-04
- 2012
- English.
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In: Gel electrophoresis-Advanced Techniques. - Rijeka, Croatia : In Tech. - 9789535104575 ; , s. 327-358
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Abstract
Subject headings
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- Over the years a number of epidemiological studies have shown that PM from combustion sources such as motor vehicles contributes to respiratory and cardiovascular morbidity and mortality.Especially so do the ultra-fine particles (UFPs) with a diameter less than 0.1 micrometer.UFPs from combustion engines are capable to translocate over the alveolar–capillary barrier. When nano-sized PM (nanoparticles, NP), which are small enough to enter the blood stream, do so they are likely to interact with plasma proteins and this protein-NP interaction will probably affect the fate of and the effects caused by the NPs in the human body. Here, by using a proteomic approach, we present results showing that several proteins indeed are associated to NPs that have in vitro been introduced to human blood plasma.
Keyword
- Proteins
- Nanoparticles
- Gelelectrophoresis
Publication and Content Type
- vet (subject category)
- kap (subject category)
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