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Nitric oxide modula...
Nitric oxide modulates captopril-mediated angiotensin-converting enzyme inhibition in porcine iliac arteries
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- Persson, Karin (author)
- Linköpings universitet,Farmakologi,Hälsouniversitetet
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- Andersson, Rolf G. G. (author)
- Linköpings universitet,Farmakologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier, 1999
- 1999
- English.
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In: European Journal of Pharmacology. - : Elsevier. - 0014-2999 .- 1879-0712. ; 385:1, s. 21-27
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The influence of the angiotensin-converting enzyme inhibitor captopril on bradykinin-and angiotensin I-induced responses with special regard to nitric oxide (NO) was studied. Auxometric tension and angiotensin-converting enzyme activity was studied in isolated porcine iliac arteries. Captopril potentiated bradykinin-induced contraction of preparations with intact endothelium; this potentiation was not seen with the kininase I inhibitor mergepta or a bradykinin B1-receptor antagonist. Captopril did not affect bradykinin-induced relaxation. The captopril-mediated increase of bradykinin-induced contraction was only seen in preparations with intact endothelium, while captopril did not affect arterial strips treated with Nω-nitro-L-arginine. Angiotensin I-induced contractions was less reduced by captopril when the strips were pretreated with Nω-nitro-L-arginine. Both captopril and the NO donor S-nitroso-N-acetyl-penicillamine inhibited angiotensin-converting enzyme activity. An additional reduction in angiotensin-converting enzyme activity was seen when S-nitroso-N-acetyl-penicillamine was added to captopril-treated preparations. In conclusion, captopril increased bradykinin-induced contraction in a NO-dependent manner. This potentiation is probably mediated by the increased metabolism of bradykinin by kininase I, and the additive angiotensin-converting enzyme inhibitory effect of captopril and NO.
Keyword
- Angiotensin-converting enzyme activity
- Bradykinin
- Captopril
- Contraction
- Nitric oxide (NO)
- Relaxation
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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