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Autoantibodies to l...
Autoantibodies to leucocyte antigens in hydralazine-associated nephritis
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- Almroth, Gabriel (author)
- Östergötlands Läns Landsting,Linköpings universitet,Njurmedicin,Hälsouniversitetet,Njurmedicinska kliniken
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- Eneström, S. (author)
- Linköpings universitet,Patologi,Hälsouniversitetet
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- Hed, J. (author)
- Linköpings universitet,Östergötlands Läns Landsting,Transfusionsmedicin och klinisk immunologi,Hälsouniversitetet
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- Samuelsson, I. (author)
- Section of Nephrology, Department of Internal Medicine. Örebro Medical Centre, Örebro, Sweden
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- Sjöström, P. (author)
- Section of Nephrology, Department of Internal Medicine. Örebro Medical Centre, Örebro, Sweden
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(creator_code:org_t)
- Wiley, 1992
- 1992
- English.
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In: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 231:1, s. 37-42
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Clinical and laboratory findings and drug history were studied in 17 patients with suspected hydralazine-associated nephritis, five of whom only had renal disease, while twelve also had extrarenal manifestations. Renal biopsies revealed extracapillary proliferative or focal segmental proliferative glomerulonephritis in 10 patients, and tubulo-interstitial nephritis in five patients. Antinuclear antibody (ANA) was found in 16 patients, but none of the 14 patients tested had antibodies to DNA. Tests for antibodies to myeloperoxidase (anti-MPO) and antibodies to neutrophil cytoplasm antigen (ANCA) were performed by ELISA. Twelve of the 14 patients tested had anti-MPO; five of these 14 patients had ANCA, while one had borderline levels. These findings suggest that hydralazine facilitates the induction of a systemic disease with multiple autoantibody production.
Keyword
- ANA
- ANCA
- anti-MPO
- hydralazine
- systemic lupus erythematosus
- vasculitis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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