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Fibrils from Synthetic Amyloid-Related Peptides Enhance Development of Experimental AA-Amyloidosis in Mice
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- Ganowiak, Katarzyna (author)
- Linköpings universitet,Patologi,Hälsouniversitetet
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- Hultman, Per (author)
- Linköpings universitet,Patologi,Hälsouniversitetet
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- Engström, Ulla (author)
- Ludwig Institute of Cancer Research, Uppsala Branch, Uppsala, Sweden
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- Gustavsson, Åsa (author)
- Linköpings universitet,Patologi,Hälsouniversitetet
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- Westermark, Per (author)
- Linköpings universitet,Patologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier BV, 1994
- English.
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In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 199:1, s. 306-312
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Amyloid enhancing factor is an incompletely characterized activity of extracts from many amyloid-containing tissues and which greatly shortens the preamyloidotic phase during experimental induction of AA-amyloidosis. In this communication we show that amyloid-like fibrils made in vitro from synthetic peptides, corresponding to segments of amyloid fibril proteins, have amyloid enhancing factor-like activity. Thus, there is a possibility that amyloid enhancing factor activity depends on small fibrils serving as nucleation centers for fibril elongation.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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