Invasive Haemophilus influenzae Disease: Epidemiology and Clinical Spectrum Before Large-scale H. influenzae Type b Vaccination

Hugosson, SvanteDepartments of Otorhinolaryngology, Örebro Medical Center Hospital, Örebro, Sweden (author)

Invasive Haemophilus influenzae Disease : Epidemiology and Clinical Spectrum Before Large-scale H. influenzae Type b Vaccination

In a prospective study between January 1987 and December 1992, 103 patients with invasive Haemophilus influenzae (Hi) infection were identified in a well-defined population before large-scale Haemophilus influenzae type b (Hib) vaccination was introduced. The incidence (cases/100,000/year) of invasive Hi infection was 5.9 for the whole population, 55 for children 0-4 years old and as high as 2.8 for adults. Hib was the predominant cause of the infection (83 cases) in children but, in adults, 13/39 (30%) cases were caused by non-typable Hi and 6/39 (19%) by Hi serotype f. Three patients (3%) died and 6 (5.8%) suffered a permanent sequel from the infection. All patients with such a sequel had invasive Hib infection. No significant difference between patients 0-6 years old and matched controls regarding the frequency of subnormal serum levels of immunoglobulins was found.

Silfverdal, Sven ArneDepartments of Paediatrics, Örebro Medical Center Hospital, Örebro, Sweden(Swepub:umu)svar0002 (author)
Garpenholt, ÖrjanDepartments of Clinical Microbiology and Immunology, Örebro Medical Center Hospital, Örebro, Sweden (author)
Esbjörner, ElisabethDepartments of Paediatrics, Örebro Medical Center Hospital, Örebro, Sweden (author)
Lindquist, BoDepartments of Paediatrics, Örebro Medical Center Hospital, Örebro, Sweden (author)
Vikerfors, ThomasDepartments of Infectious Diseases, Örebro Medical Center Hospital, Örebro, Sweden (author)
Werner, BoDepartments of Community Medicine and Public Health, Örebro Medical Center Hospital, Örebro, Sweden (author)
Olcén, PerDepartments of Clinical Microbiology and Immunology, Örebro Medical Center Hospital, Örebro, Sweden(Swepub:liu)perol69 (author)
Departments of Otorhinolaryngology, Örebro Medical Center Hospital, Örebro, SwedenDepartments of Paediatrics, Örebro Medical Center Hospital, Örebro, Sweden (creator_code:org_t)

In:Scandinavian Journal of Infectious Diseases: Informa UK Limited27:1, s. 63-670036-55481651-1980

By the author/editor: Hugosson, Svante; Silfverdal, Sven ...; Garpenholt, Örja ...; Esbjörner, Elisa ...; Lindquist, Bo; Vikerfors, Thoma ...; show more...; Werner, Bo; Olcén, Per; show less...

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