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Laser-induced fluorescence in malignant and normal tissue in mice injected with two different carotenoporphyrins
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- Nilsson, Henrik (author)
- Lund University Medical Laser Center, Lund Institute of Technology, Lund, Sweden
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- Johansson, Jonas (author)
- Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Lund University Medical Laser Center and Department of Physics, Lund Institute of Technology, Lund, Sweden
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- Svanberg, Katarina (author)
- Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Lund University Medical Laser Center, Lund Institute of Technology and the Department of Oncology, Lund University Hospital, Lund, Sweden
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 1994
- 1994
- English.
- In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 70:5, s. 873-879
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)3] and a trimethoxylated carotenoporphyrin [CP(OMe)3] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me)3 and about 6:1 for CP(OMe)3 in terms of the background-free fluorescence intensity, which peaked at about 655 nm. By including the endogenous tissue fluorescence, the contrast was further enhanced by a factor of approximately 2.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- Nilsson, Henrik
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- Svanberg, Sune
- Jori, G.
- Reddi, E.
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- Segalla, A.
- Gust, D.
- Moore, A. L.
- Moore, T. A.
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- MEDICAL AND HEALTH SCIENCES
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- Linköping University
- Lund University
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