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Population-based re...
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Nyström, Fredrik H.Linköpings universitet,Endokrinologi,Internmedicin,Hälsouniversitetet
(author)
Population-based reference values for IGF-I and IGF-binding protein-1 : Relations with metabolic and anthropometric variables
- Article/chapterEnglish1997
Publisher, publication year, extent ...
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Oxford University Press (OUP),1997
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-81631
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-81631URI
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https://doi.org/10.1530/eje.0.1360165DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Population-based reference values for IGF-I and IGF-binding protein-1 (IGFBP-1) have been established. One hundred and one women and the same number of men, 20–70 years old, were randomly selected from the population registry in the community of Linköping. Participation rate was 67%. Venous blood was drawn in the fasting state. Serum IGF-I was measured by RIA after acid-ethanol extraction and IGFBP-1 was determined by ELISA. IGF-I levels did not differ between genders and the decline with age was similar in men and women (men: Y=366–3·28×age (years), r =−0·61, P<0·0001; women: Y=386–3·49×age, r =−0·57, P<0·0001, P=0·4 for difference in slope). There were negative correlations between IGF-I and plasma lipids and blood pressure in both genders, but none was independent of age. Serum angiotensin-converting enzyme activity correlated positively with IGF-I in men independently from age (r =0·21, P=0·01). The distribution of IGFBP-1 was positively skewed and it was higher in women than in men (5·9±4·8 μg/l and 4·0±3·3 μg/l respectively; Mann–Whitney, P=0·002). In men and in the women not taking oestrogen, IGFBP-1 correlated positively with age (Spearman rank correlation (Spearman): men: r=0·32, P=0·002; women: r=0·24, P=0·03). C-peptide correlated negatively (Spearman: men: r =−0·38, P=0·002; women: r =−0·49, P<0·000) and sex hormone binding globulin positively with IGFBP-1 (Spearman: men: r=0·50, P<0·0001; women: r =0·55, P<0·0001).
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Added entries (persons, corporate bodies, meetings, titles ...)
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Öhmar, Peter K.Linköpings universitet,Endokrinologi,Hälsouniversitetet
(author)
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Ekman, Bertil Å.Linköpings universitet,Endokrinologi,Hälsouniversitetet(Swepub:liu)berek83
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Österlund, Maria K.Linköpings universitet,Endokrinologi,Hälsouniversitetet
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Karlberg, Bengt E.Linköpings universitet,Endokrinologi,Hälsouniversitetet
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Arnqvist, Hans J.Linköpings universitet,Endokrinologi,Hälsouniversitetet(Swepub:liu)hanar64
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Linköpings universitetEndokrinologi
(creator_code:org_t)
Related titles
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In:European Journal of Endocrinology: Oxford University Press (OUP)136:2, s. 165-1720804-46431479-683X
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