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Suppression of macr...
Suppression of macrophage activation with CNI-1493 increases survival in infant rats with systemic Haemophilus influenzae infection
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- Granert, Carl (author)
- Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
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- Abdalla, Hana (author)
- Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
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- Lindquist, Lars (author)
- Karolinska Institutet
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- Diab, Asim (author)
- Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
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- Bahkiet, Moiz (author)
- Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
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- Tracey, Kevin J. (author)
- Laboratory of Biomedical Science, North Shore University Hospital, Manhasset, New York
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- Andersson, Jan (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 68:9, s. 5329-5334
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- CNI-1493, a potent macrophage deactivator, was used to treat infant rats systemically infected with Haemophilus influenzae type b (Hib). CNI-1493 was injected 1 h prior to bacterial inoculation and 24 h later and resulted in a 75 percent increased rate of survival compared to that for untreated controls. The effect of CNI-1493 on the inflammatory response was studied by immunohistochemical detection of individual tumor necrosis factor alpha (TNF-α)-, interleukin 1 beta (IL-1β)-, and gamma interferon (IFN-γ)-producing cells in the spleen. A significant reduction of the incidence of TNF-α- and IL-1β-expressing cells was found for CNI-1493-treated animals. IFN-γ expression was not suppressed by CNI-1493, indicating that cytokine inhibition was specific in macrophages. CNI-1493 significantly reduced the number of infiltrating granulocytes in the brain from that for controls. This study provides evidence that CNI-1493 protects against lethal Hib infection by deactivating the inflammatory cascade in infant rats.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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