Search: onr:"swepub:oai:DiVA.org:liu-81987" >
CD38 :
CD38 : a NAADP degrading enzyme
-
- Schmid, Frederike (author)
- University Medical Centre Hamburg-Eppendorf, Germany
-
- Bruhn, Sören, 1976- (author)
- University Medical Centre Hamburg-Eppendorf, Germany
-
- Weber, Karin (author)
- University Medical Centre Hamburg-Eppendorf, Germany
-
show more...
-
- Mitrücker, Hans (author)
- University Medical Centre Hamburg-Eppendorf, Germany
-
- Guse, Andreas (author)
- University Medical Centre Hamburg-Eppendorf, Germany
-
show less...
-
(creator_code:org_t)
- 2011-10-19
- 2011
- English.
-
In: FEBS Letters. - : Elsevier. - 0014-5793 .- 1873-3468. ; 585:22, s. 3544-3548
- Related links:
-
https://febs.onlinel...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The role of the multifunctional enzyme CD38 in formation of the Ca2+-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADPdegrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.
Keyword
- Calcium signalling; NAADP; CD38; Jurkat T lymphocyte
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database