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- Schmid, FrederikeUniversity Medical Centre Hamburg-Eppendorf, Germany (author)
CD38 : a NAADP degrading enzyme
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2011-10-19
- Elsevier,2011
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-81987
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-81987URI
- https://doi.org/10.1016/j.febslet.2011.10.017DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The role of the multifunctional enzyme CD38 in formation of the Ca2+-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADPdegrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.
Subject headings and genre
- Calcium signalling; NAADP; CD38; Jurkat T lymphocyte
Added entries (persons, corporate bodies, meetings, titles ...)
- Bruhn, Sören,1976-University Medical Centre Hamburg-Eppendorf, Germany(Swepub:liu)sorbr27 (author)
- Weber, KarinUniversity Medical Centre Hamburg-Eppendorf, Germany (author)
- Mitrücker, HansUniversity Medical Centre Hamburg-Eppendorf, Germany (author)
- Guse, AndreasUniversity Medical Centre Hamburg-Eppendorf, Germany (author)
- University Medical Centre Hamburg-Eppendorf, Germany (creator_code:org_t)
Related titles
- In:FEBS Letters: Elsevier585:22, s. 3544-35480014-57931873-3468
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