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CD38 :
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Schmid, FrederikeUniversity Medical Centre Hamburg-Eppendorf, Germany
(author)
CD38 : a NAADP degrading enzyme
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-10-19
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Elsevier,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-81987
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-81987URI
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https://doi.org/10.1016/j.febslet.2011.10.017DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The role of the multifunctional enzyme CD38 in formation of the Ca2+-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADPdegrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.
Subject headings and genre
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Calcium signalling; NAADP; CD38; Jurkat T lymphocyte
Added entries (persons, corporate bodies, meetings, titles ...)
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Bruhn, Sören,1976-University Medical Centre Hamburg-Eppendorf, Germany(Swepub:liu)sorbr27
(author)
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Weber, KarinUniversity Medical Centre Hamburg-Eppendorf, Germany
(author)
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Mitrücker, HansUniversity Medical Centre Hamburg-Eppendorf, Germany
(author)
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Guse, AndreasUniversity Medical Centre Hamburg-Eppendorf, Germany
(author)
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University Medical Centre Hamburg-Eppendorf, Germany
(creator_code:org_t)
Related titles
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In:FEBS Letters: Elsevier585:22, s. 3544-35480014-57931873-3468
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