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Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?

Machaczka, Maciej (author)
Karolinska Institutet,Karolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden
Johansson, Jan-Erik (author)
Sahlgrens University Hospital, Sweden
Remberger, Mats (author)
Karolinska Institute, Sweden
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Hallböök, Helene (author)
Uppsala universitet,Karolinska Institutet,Hematologi,University of Uppsala Hospital, Sweden
Malm, Claes (author)
Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US
Lazarevic, Vladimir (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden
Wahlin, Anders (author)
Umeå University, Sweden
Omar, Hamdy (author)
Karolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden
Juliusson, Gunnar (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden
Kimby, Eva (author)
Karolinska Institutet,Karolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden
Hägglund, Hans (author)
Uppsala universitet,Hematologi,Karolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden
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 (creator_code:org_t)
2012-03-16
2012
English.
In: Leukemia and Lymphoma. - : Informa Healthcare. - 1042-8194 .- 1029-2403. ; 53:9, s. 1699-1705
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved andgt; 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with andlt;= 90% donor T-cell engraftment, they showed favorable PFS at 1 year (82% vs. 33%, p = 0.002) and better long-term PFS and OS (p = 0.002 and 0.046, respectively). Donor T-cell engraftment of andgt; 90% at 3 months after RIC allo-SCT for CLL seems to predict favorable short-term and long-term outcome.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Allogeneic stem cell transplant
chronic lymphocytic leukemia
T-cell
donor engraftment
MEDICINE
MEDICIN
Allogeneic stem cell transplant
chronic lymphocytic leukemia
T-cell
donor engraftment

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