onr:"swepub:oai:DiVA.org:liu-82065"
Search: onr:"swepub:oai:DiVA.org:liu-82065" > Increased serum lev...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Zhao, Zeng-RenHebei Medical University, Peoples R China Hebei Medical University, Peoples R China (author)
Increased serum level of Nup88 protein is associated with the development of colorectal cancer
- Article/chapterEnglish2012
Publisher, publication year, extent ...
- 2011-08-24
- Humana Press (Springer Imprint),2012
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-82065
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-82065URI
- https://doi.org/10.1007/s12032-011-0047-1DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Funding Agencies|National Natural Science Foundation of China|30772115|
- Nucleoporin88 (Nup88) has been shown to be overexpressed in a wide variety of malignancies including colorectal cancer (CRC). However, no study about serum Nup88 in human CRC was reported. Therefore, in this study, we investigated the level of serum Nup88 protein and its relationships with clinicopathological variables in CRC. The serum concentration of Nup88 protein was determined by a quantitative sandwich enzyme-linked immunosorbent assay (ELISA) in 118 pre-operative serum samples, 66 post-operative and 96 healthy controls. Among the patients, the levels of CEA (n = 91) and CA19-9 (n = 87) in the pre-operative serum were measured, and DNA sequencing was performed in 12 CRCs and 2 samples from non-cancerous colon tissue. In the same patients, the level of pre-operative serum Nup88 was significantly higher than that of post-operative Nup88 (P = 0.021). Furthermore, the level of pre-operative Nup88 was positively related to the depth of tumor invasion (P = 0.002) and advanced stage (P = 0.001). The level of pre-operative Nup88 in the left colon tended to be higher than that in the right colon and the rectum (P = 0.063). DNA sequencing results showed that there were two single nucleotide polymorphisms, distributed in exon 6 (NM_002532.3:c.1044Gandgt;A (ACG-ACA, Thr -andgt; Thr) and exon 10 (NM_002532.3: c.1389Aandgt;T, CCA-CCT, Pro -andgt; Pro). Serum Nup88 might be a candidate for a new biomarker implicated in the development and aggressiveness of CRCs.
Subject headings and genre
- Nup88
- Serum
- Colorectal cancer
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Zhang, Li-JingHebei Medical University, Peoples R China (author)
- Wang, Yuan-YuanHebei Medical University, Peoples R China (author)
- Li, FangHebei Medical University, Peoples R China (author)
- Wang, Ming-WeiHebei Medical University, Peoples R China (author)
- Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
- Hebei Medical University, Peoples R China Hebei Medical University, Peoples R ChinaHebei Medical University, Peoples R China (creator_code:org_t)
Related titles
- In:Medical Oncology: Humana Press (Springer Imprint)29:3, s. 1789-17951357-05601559-131X
Internet link
Find in a library
- Medical Oncology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Zhao, Zeng-Ren
- Zhang, Li-Jing
- Wang, Yuan-Yuan
- Li, Fang
- Wang, Ming-Wei
- Sun, Xiao-Feng
- Articles in the publication
- Medical Oncology
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
