Maternal serum levels of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to body weight and composition of mother and infant

• Objectives: To investigate the following relationships: 1) maternal body weight and composition versus insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 in maternal serum before and during pregnancy, and 2) IGF-I and IGFBP-1 in maternal serum during pregnancy versus infant birth weight, body composition and ponderal index.Study design: Serum was collected from 23 healthy women before pregnancy, and in weeks 14, 32 and 35 of pregnancy. On these occasions maternal body weight and composition were assessed. Weight, length and body composition of the newborn were measured. Linear and multiple linear regression analyses were applied.Results: Women with the lowest body weight and body fat content had the largest decreases in IGF-I in early pregnancy. During pregnancy maternal fat-free body weight was positively related to IGF-I, whereas body fat was inversely related to IGFBP-1. Maternal body weight before pregnancy and IGF-I in week 14 of gestation explained 47 % of the variation in birth weight.Conclusion: The maternal IGF-system may be a mediator of the effect of maternal nutritional status on fetal growth.

Keyword

MEDICINE

MEDICIN

Publication and Content Type

vet (subject category)

ovr (subject category)