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Impact of cytogenet...
Impact of cytogenetics risk on outcome after reduced intensity conditioning allo-SCT from an HLA-identical sibling for patients with AML in first CR: a report from the acute leukemia working party of EBMT
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- Chevallier, P (author)
- CHU Hotel Dieu, France
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- Labopin, M (author)
- University of Paris 06, France
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- Milpied, N (author)
- CHU Bordeaux, France
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- Cornelissen, J J (author)
- Erasmus MC Daniel den Hoed Cancer Centre, Netherlands
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- Blaise, D (author)
- Institute Paoli Calmette, France
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- Petersen, E (author)
- University of Medical Centre Utrecht, Netherlands
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- Sandstedt, A (author)
- Östergötlands Läns Landsting,Hematologiska kliniken US
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- Goker, H (author)
- Hacettepe University, Turkey
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- Socie, G (author)
- Hop St Louis, France
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- Rocha, V (author)
- Hop St Louis, France
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- Mohty, M (author)
- n/a
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(creator_code:org_t)
- 2012-04-16
- 2012
- English.
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In: Bone Marrow Transplantation. - : Nature Publishing Group. - 0268-3369 .- 1476-5365. ; 47:11, s. 1442-1447
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- So far the impact of cytogenetics risk on outcome in the context of reduced intensity conditioning (RIC) allo-SCT has been poorly studied. We have identified 378 AML patients in first CR who underwent RIC allo-SCT from an HLA-matched sibling donor between 2000 and 2007 reported to the European Group for Bone and Marrow Transplantation and for whom detailed cytogenetics data were available (good risk: n = 21; intermediate risk: n = 304; and poor risk: n = 53). With a median follow-up of 24 months (range: 1-93), 2-year non-relapse mortality, relapse rate (RR), leukemia-free survival (LFS) and OS were 14%, 31%, 55% and 61%, respectively. Cytogenetics was significantly associated with RR (good risk: 10%; intermediate risk: 28%; and poor risk: 55% at 2 years, Pandlt;0.0001) and LFS (good risk: 64%; intermediate risk: 57%; and poor risk: 38% at 2 years, P = 0.003). In a multivariate analysis, RR and LFS were significantly higher and lower, respectively, in the high-risk cytogenetics group (P = 0.001, P = 0.004) and in patients with a higher WBC at diagnosis (andgt;10 x 10(9)/L) (Pandlt;0.001, P = 0.004). As documented in the setting of myeloablative allo-SCT, patients with poor cytogenetics had increased RR and decreased LFS after RIC allo-SCT, requiring new prospective strategies to improve results in this subgroup.
Keyword
- Allo-SCT
- cytogenetics
- RIC
- AML
- CR
- sibling donor
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chevallier, P
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Labopin, M
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Milpied, N
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Cornelissen, J J
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Blaise, D
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Petersen, E
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show more...
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Sandstedt, A
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Goker, H
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Socie, G
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Rocha, V
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Mohty, M
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show less...
- Articles in the publication
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Bone Marrow Tran ...
- By the university
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Linköping University