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Cancer stem cell markers in common cancers - therapeutic implications

Klonisch, Thomas (author)
Department of Human Anatomy and Cell Sciences, Winnipeg, Canada
Wiechec, Emilia (author)
Manitoba Institute of Cell Biology, CancerCare Manitoba; Department of Human Genetics, University of Aarhus, Aarhus, Denmark
Hombach-Klonisch, Sabine (author)
Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, R3E 0W3, MB, Canada
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Ande, Sudharsana R. (author)
Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, R3E 0V9, MB, Canada; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, R3E 0W3, MB, Canada
Wesselborg, Sebastian (author)
Department of Internal Medicine I, University of Tübingen, D-72076 Tübingen, Germany
Schulze-Osthoff, Klaus (author)
Interfaculty Institute for Biochemistry, University of Tübingen, Germany
Los, Marek Jan (author)
University of Manitoba, Winnipeg, Canada
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 (creator_code:org_t)
Elsevier, 2008
2008
English.
In: Trends in Molecular Medicine. - : Elsevier. - 1471-4914 .- 1471-499X. ; 14:10, s. 450-460
  • Research review (peer-reviewed)
Abstract Subject headings
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  • Rapid advances in the cancer stem cell (CSC) field have provided cause for optimism for the development of more reliable cancer therapies in the future. Strategies aimed at efficient targeting of CSCs are becoming important for monitoring the progress of cancer therapy and for evaluating new therapeutic approaches. Here, we characterize and compare the specific markers that have been found to be present on stem cells, cancer cells and CSCs in selected tissues (colon, breast, liver, pancreas and prostate). We then discuss future directions of this intriguing new research field in the context of new diagnostic and therapeutic opportunities.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

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