Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design

Anticancer drugs of tomorrow : apoptotic pathways as targets for drug design

Los, Marek Jan (author): Institute of Experimental Dermatology, University of Muenster, Germany

Burek, C. J. (author): Institute of Experimental Dermatology, University of Muenster, Germany

Stroh, C. (author): Institute of Experimental Dermatology, University of Muenster, Germany

Benedyk, K. (author): Dept of Tumor Biology Oncology Center, Maria Sklodowska-Curie Memorial Institute, Wybrzeze Armii Krajowej 15, PL-44100 Gliwice, Poland

Hug, H. (author): TheraSTrat AGGewerbestrasse 25, CH-4123, Allschwil, Switzerland

Mackiewicz, A. (author): Dept of Cancer Immunology, University of Medical Sciences, at Great-Poland Cancer Center, Poznan, Poland

(creator_code:org_t)

Elsevier, 2003
2003
English.
In: Drug Discovery Today. - : Elsevier. - 1359-6446 .- 1878-5832. ; 8:2, s. 67-77

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Abstract Subject headings

Apoptosis or programmed cell death is a set of ordered events that enables the selective removal of cells from tissue and is essential for homeostasis and proper function of multicellular organisms. Components of this signaling network, which include ligands, such as CD95, tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand, as well as downstream molecules, such as caspases, Bcl-2 family members, and inhibitor-of-apoptosis proteins, which trigger and regulate apoptosis, are crucial targets for conventional drug development and gene therapy of cancer and other diseases. Here, we focus on apoptotic pathways and propose new potential molecular targets that could prove effective in controlling cell death in the clinical setting.

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

By the author/editor: Los, Marek Jan; Burek, C. J.; Stroh, C.; Benedyk, K.; Hug, H.; Mackiewicz, A.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

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