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Caspases - Their ro...
Caspases - Their role in apoptosis and other physiological processes as revealed by knock-out studies
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- Sadowski-Debbing, K. (författare)
- Clinic for Craniomaxillofacial Surgery, Ahaus, Germany
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- Coy, J. F. (författare)
- MTM Laboratories AG, Im Neuenheimer Feld 519, D-69120 Heidelberg, Germany
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- Mier, W. (författare)
- Institute of Nuclear Medicine, University of Heidelberg, D-69120 Heidelberg, Germany
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- Hug, H. (författare)
- University Childrens Hospital, Prittwitzstr. 43, D-89075 Ulm, Germany
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- Los, Marek Jan (författare)
- Department of Immunology and Cell Biology, University of M uenster D-48149 Muenster, Germany
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Archivum Immunologiae et Therapiae Experimentalis. - 0004-069X .- 1661-4917. ; 50:1, s. 19-34
- Relaterad länk:
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http://www2.iitd.pan...
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https://liu.diva-por... (primary) (Raw object)
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Abstract
Ämnesord
Stäng
- Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is carefully controlled by a philogenetically conserved death program, which is indispensable for the homeostasis and development of higher organisms. Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. In vitro studies have demonstrated the requirement of caspase activity for both the triggering phase as well as the execution of apoptosis, thus providing a molecular base for the time-tuning of this process by pharmacological agents. The precise roles of the individual caspases in vivo and their functional relation to each other have been best demonstrated in genetically modified animals. The generation of single caspase-deficient mice have confirmed most of the data obtained in vitro and exposed some new aspects previously undetected in the cell culture system. Interestingly, inactivation of many caspases revealed not only their expected participation in apoptotic events as well as in the maturation of cytokines, but also provided hints about the role of at least some caspases in cell differentiation and stimulatory responses. In this review we will discuss what these studies have unveiled about the role of individual caspases in development, apoptosis, and inflammation, with particular focus on their role beyond the apoptotic process.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- apo-1/fas receptor/ligand system
- caspase
- cell cycle
- Cell Death
- cytochrome-c release
- development
- drug-induced apoptosis
- fas-mediated apoptosis
- gamma-inducing factor
- il-1-beta-converting enzyme
- Inflammation
- interleukin-1-beta converting-enzyme
- ischemic brain-injury
- mice deficient
- programmed cell-death
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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