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Electrochemical imm...
Electrochemical immunosensor with N-doped graphene-modified electrode for label-free detection of the breast cancer biomarker CA 15-3
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- Li, He (author)
- Jiangsu University, Zhenjiang, China and University of Jinan, China
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- He, Jing (author)
- University of Jinan, China
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- Li, Songjun (author)
- Jiangsu University, Zhenjiang, China
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- Turner, Anthony, 1950- (author)
- Linköpings universitet,Biosensorer och bioelektronik,Tekniska högskolan
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(creator_code:org_t)
- Elsevier, 2013
- 2013
- English.
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In: Biosensors & bioelectronics. - : Elsevier. - 0956-5663 .- 1873-4235. ; 43, s. 25-29
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Highly sensitive and label-free detection of the biomarker carbohydrate antigen 15-3 (CA 15-3) remains a challenge in the diagnosis of breast cancer. Here, a novel electrochemical immunosensor capable of sensitive and label-free detection of CA 15-3 is reported. This unique immunosensor, equipped with a highly conductive graphene (i.e., N-doped graphene sheets)-modified electrode, exhibited significantly increased electron transfer and high sensitivity toward CA 15-3. This novel immunosensor, with a low detection limit of 0.012U/mL, worked well over a broad linear range of 0.1-20U/mL. Unlike conventional immunosensors, which usually involve complicated label processing and time-consuming separations, the use of highly conductive graphene avoids the need for labels and is simple in nature. The strategy developed for this immunosensor provides a promising approach for clinical research and diagnostic applications.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Keyword
- Electrochemical immunosensor; Graphene sheets; CA15-3; Label-free detection
Publication and Content Type
- ref (subject category)
- art (subject category)
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