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Shape engineering v...
Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
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- Sen Karaman, Didem (author)
- Abo Akad University, Finland
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- Desai, Diti (author)
- Abo Akad University, Finland Maharaja Sayajirao University of Baroda, India
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- Senthilkumar, Rajendran (author)
- Abo Akad University, Finland
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- Johansson, Emma (author)
- Linköpings universitet,Nanostrukturerade material,Tekniska högskolan
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- Ratts, Natalie (author)
- Abo Akad University, Finland Abo Akad University, Finland Abo Akad University, Finland University of Turku, Finland
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- Odén, Magnus (author)
- Linköpings universitet,Nanostrukturerade material,Tekniska högskolan
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- E Eriksson, John (author)
- Abo Akad University, Finland
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- Sahlgren, Cecilia (author)
- Abo Akad University, Finland Abo Akad University, Finland University of Turku, Finland
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- Toivola, Diana M. (author)
- Abo Akad University, Finland Turku Centre Disease Modeling, Finland
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- Rosenholm, Jessica M. (author)
- Abo Akad University, Finland
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(creator_code:org_t)
- SpringerOpen, 2012
- 2012
- English.
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In: Nanoscale Research Letters. - : SpringerOpen. - 1931-7573 .- 1556-276X. ; 7:358
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In nanomedicine, physicochemical properties of the nanocarrier affect the nanoparticles pharmacokinetics and biodistribution, which are also decisive for the passive targeting and nonspecific cellular uptake of nanoparticles. Size and surface charge are, consequently, two main determining factors in nanomedicine applications. Another important parameter which has received much less attention is the morphology (shape) of the nanocarrier. In order to investigate the morphology effect on the extent of cellular internalization, two similarly sized but differently shaped rod-like and spherical mesoporous silica nanoparticles were synthesized, characterized and functionalized to yield different surface charges. The uptake in two different cancer cell lines was investigated as a function of particle shape, coating (organic modification), surface charge and dose. According to the presented results, particle morphology is a decisive property regardless of both the different surface charges and doses tested, whereby rod-like particles internalized more efficiently in both cell lines. At lower doses whereby the shape-induced advantage is less dominant, charge-induced effects can, however, be used to fine-tune the cellular uptake as a prospective secondary uptake regulator for tight dose control in nanoparticle-based drug formulations.
Keyword
- mesoporous silica nanoparticles
- surface functionalization
- rod-shaped particles
- surface charge
- cellular internalization
- nanomedicine
- TECHNOLOGY
- TEKNIKVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sen Karaman, Did ...
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Desai, Diti
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Senthilkumar, Ra ...
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Johansson, Emma
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Ratts, Natalie
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Odén, Magnus
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show more...
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E Eriksson, John
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Sahlgren, Cecili ...
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Toivola, Diana M ...
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Rosenholm, Jessi ...
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show less...
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Nanoscale Resear ...
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Linköping University