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Effect of Local vs....
Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw
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- Abtahi, Jahan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Käkkliniken US
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- Agholme, Fredrik (author)
- Linköpings universitet,Ortopedi,Hälsouniversitetet
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- Sandberg, Olof (author)
- Linköpings universitet,Ortopedi,Hälsouniversitetet
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- Aspenberg, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Ortopedkliniken i Linköping
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(creator_code:org_t)
- 2012-12-21
- 2013
- English.
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In: Journal of Dental Research. - : Sage Publications. - 0022-0345 .- 1544-0591. ; 92:3, s. 279-283
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without complications in a setting where systemic treatment induces ONJ. Forty rats were randomly allocated to 4 groups of 10. All groups received a titanium implant inserted in an extraction socket. Group I received the implants only. Group II received dexamethasone (0.5 mg/kg). Group III received dexamethasone as above plus alendronate (200 µg/kg). Group IV received zoledronate-coated implants and dexamethasone as above. The animals were sacrificed 2 weeks after tooth extraction. All 10 animals with systemic alendronate treatment developed large ONJ-like changes, while all with local treatment were completely healed. Implant removal torque was higher for the bisphosphonate-coated implants compared with the other groups (p < 0.03 for each comparison). Micro-computed tomography of the maxilla showed more bone loss in the systemic alendronate group compared with groups receiving local treatment (p = 0.001). Local bisphosphonate treatment appears to improve implant fixation in a setting where systemic treatment caused ONJ.
Publication and Content Type
- ref (subject category)
- art (subject category)
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