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Effect of Local vs....
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Abtahi, JahanÖstergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Käkkliniken US
(author)
Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-12-21
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Sage Publications,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-89667
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89667URI
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https://doi.org/10.1177/0022034512472335DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without complications in a setting where systemic treatment induces ONJ. Forty rats were randomly allocated to 4 groups of 10. All groups received a titanium implant inserted in an extraction socket. Group I received the implants only. Group II received dexamethasone (0.5 mg/kg). Group III received dexamethasone as above plus alendronate (200 µg/kg). Group IV received zoledronate-coated implants and dexamethasone as above. The animals were sacrificed 2 weeks after tooth extraction. All 10 animals with systemic alendronate treatment developed large ONJ-like changes, while all with local treatment were completely healed. Implant removal torque was higher for the bisphosphonate-coated implants compared with the other groups (p < 0.03 for each comparison). Micro-computed tomography of the maxilla showed more bone loss in the systemic alendronate group compared with groups receiving local treatment (p = 0.001). Local bisphosphonate treatment appears to improve implant fixation in a setting where systemic treatment caused ONJ.
Added entries (persons, corporate bodies, meetings, titles ...)
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Agholme, FredrikLinköpings universitet,Ortopedi,Hälsouniversitetet(Swepub:liu)freag09
(author)
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Sandberg, OlofLinköpings universitet,Ortopedi,Hälsouniversitetet(Swepub:liu)olosa45
(author)
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Aspenberg, PerÖstergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Ortopedkliniken i Linköping(Swepub:liu)peras36
(author)
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Linköpings universitetOrtopedi
(creator_code:org_t)
Related titles
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In:Journal of Dental Research: Sage Publications92:3, s. 279-2830022-03451544-0591
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