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Interconnections be...
Interconnections between apoptotic, autophagic and necrotic pathways : implications for cancer therapy development
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- Jain, Mayur Vilas (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Paczulla, Anna M. (author)
- University of Tubingen, Germany
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- Klonisch, Thomas (author)
- University of Manitoba, Canada
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- Dimgba, Florence N. (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Rao, Sahana (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Roberg, Karin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öron- näsa- och halskliniken US
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- Schweizer, Frank (author)
- University of Manitoba, Canada
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- Lengerke, Claudia (author)
- University of Tubingen, Germany
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- Davoodpour, Padideh (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
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- Palicharla, Vivek R. (author)
- Centre DNA Fingerprinting and Diagnost CDFD, India
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- Maddika, Subbareddy (author)
- Centre DNA Fingerprinting and Diagnost CDFD, India
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- Los, Marek Jan (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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(creator_code:org_t)
- 2013-01-10
- 2013
- English.
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In: Journal of Cellular and Molecular Medicine (Print). - : Wiley-Blackwell. - 1582-1838 .- 1582-4934. ; 17:1, s. 12-29
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Abstract
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- The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by the development of several experimental anticancer- and anti-ischaemia (stroke or myocardial infarction) drugs. Activation of apoptotic pathways or the removal of cellular apoptotic inhibitors has been suggested to aid cancer therapy and the inhibition of apoptosis was thought to limit ischaemia-induced damage. However, initial clinical studies on apoptosis-modulating drugs led to unexpected results in different clinical conditions and this may have been due to co-effects on non-apoptotic interconnected cell death mechanisms and the yin-yang role of autophagy in survival versus cell death. In this review, we extend the analysis of cell death beyond apoptosis. Upon introduction of molecular pathways governing autophagy and necrosis (also called necroptosis or programmed necrosis), we focus on the interconnected character of cell death signals and on the shared cell death processes involving mitochondria (e.g. mitophagy and mitoptosis) and molecular signals playing prominent roles in multiple pathways (e.g. Bcl2-family members and p53). We also briefly highlight stress-induced cell senescence that plays a role not only in organismal ageing but also offers the development of novel anticancer strategies. Finally, we briefly illustrate the interconnected character of cell death forms in clinical settings while discussing irradiation-induced mitotic catastrophe. The signalling pathways are discussed in their relation to cancer biology and treatment approaches.
Keyword
- Bcl2 family
- p53
- Cancer therapy
- Erk
- FOXO
- PI3-K
- Rheb
- S6K
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Jain, Mayur Vila ...
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Paczulla, Anna M ...
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Klonisch, Thomas
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Dimgba, Florence ...
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Rao, Sahana
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Roberg, Karin
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show more...
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Schweizer, Frank
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Lengerke, Claudi ...
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Davoodpour, Padi ...
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Palicharla, Vive ...
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Maddika, Subbare ...
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Los, Marek Jan
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- Articles in the publication
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Journal of Cellu ...
- By the university
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Linköping University