Search: onr:"swepub:oai:DiVA.org:liu-89965" >
GAD65 antigen thera...
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Ludvigsson, JohnnyLinköping University,Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
(author)
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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Massachusetts Medical Society,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-89965
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89965URI
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https://doi.org/10.1056/NEJMoa1107096DOI
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https://lup.lub.lu.se/record/de435ab5-1cd0-439f-a07b-2e8f2a47b88fURI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Diamyd Medical||Swedish Child Diabetes Foundation (Barndiabetesfonden)
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BACKGROUND: The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.METHODS: We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng per milliliter (0.1 nmol per liter), and detectable serum GAD65 autoantibodies. Within 3 months after diagnosis, patients were randomly assigned to receive one of three study treatments: four doses of GAD-alum, two doses of GAD-alum followed by two doses of placebo, or four doses of placebo. The primary outcome was the change in the stimulated serum C-peptide level (after a mixed-meal tolerance test) between the baseline visit and the 15-month visit. Secondary outcomes included the glycated hemoglobin level, mean daily insulin dose, rate of hypoglycemia, and fasting and maximum stimulated C-peptide levels.RESULTS: The stimulated C-peptide level declined to a similar degree in all study groups, and the primary outcome at 15 months did not differ significantly between the combined active-drug groups and the placebo group (P=0.10). The use of GAD-alum as compared with placebo did not affect the insulin dose, glycated hemoglobin level, or hypoglycemia rate. Adverse events were infrequent and mild in the three groups, with no significant differences.CONCLUSIONS: Treatment with GAD-alum did not significantly reduce the loss of stimulated C peptide or improve clinical outcomes over a 15-month period.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Krisky, DavidDiamyd Medical, Pittsburgh,Diamyd Medical, US
(author)
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Casas, RosauraLinköping University,Linköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)rosca56
(author)
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Battelino, TadejUniversity Medical Center–University Children's Hospital, Faculty of Medicine, Ljubljana, Slovenia
(author)
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Castaño, LuisHospital de Cruces–University of Basque Country, Barakaldo, Bizkaia, Spain
(author)
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Greening, JamesDepartment of Paediatrics, Leicester Royal Infirmary, Leicester, UK
(author)
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Kordonouri, OlgaDiabetes Center for Children and Adolescents, Kinderkrankenhaus auf der Bult, Hannover, Germany,Children's Hospital Auf der Bult
(author)
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Otonkoski, TimoChildren's Hospital, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
(author)
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Pozzilli, PaoloUniversity Campus Bio-Medico, Rome, Italy
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Robert, Jean-JacquesHôpital Necker–Enfants Malades, Université René Descartes Paris 5, Paris, France
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Veeze, Henk J.Stichting Diabeter, Rotterdam, the Netherlands
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Palmer, JerryDepartment of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, USA
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Samuelsson, UlfÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)ulfsa43
(author)
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Elding Larsson, HelenaLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)pedi-hla
(author)
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Åman, JanÖrebro universitet, Sweden
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Kärdell, Gunilla
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Neiderud, JanHelsingborgs lasarett, Sweden
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Lundström, GöranLänssjukhuset Kalmar, Sweden
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Albinsson, EvaLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet(Swepub:liu)evaal82
(author)
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Carlsson, AnnelieLund University,Lunds universitet,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Pediatric Autoimmunity,Lund University Research Groups(Swepub:lu)med-acs
(author)
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Nordvall, MariaÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping
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Fors, HansSahlgrenska akademin vid Göteborgs universitet, Sweden
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Arvidsson, Carl-GöranCentrallasarettet, Västerås, Sweden
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Edvardson, StigCentrallasarettet, Växjö, Sweden
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Hanås, RagnarLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)ragha78
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Larsson, Karin
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Rathsman, BjörnSachsska Barnsjukhuset, Stockholm, Sweden
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Forsgren, Henrik
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Desaix, Helena
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Forsander, GunGöteborg University, Sweden
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Nilsson, Nils-ÖstenLasarettet i Halmstad, Sweden
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Åkesson, Carl-Göran
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Keskinen, PäiviUniversity of Tampere, Finland
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Veijola, RiittaUleåborgs universitetssjukhus, Finland
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Talvitie, Timo
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Raile, KlemensCharite, Berlin, Germany
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Kapellen, ThomasUniversity of Leipzig, Germany
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Burger, Walter
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Neu, AndreasUniversity Children's Hospital, Tuebingen, Germany
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Engelsberger, Ilse
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Heidtmann, BettinaCatholic Children’s Hospital Wilhelmstift, Hamburg, Germany
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Bechtold, Suzanne
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Leslie, DavidBlizard Institute, Queen Mary University of London, UK
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Chiarelli, FrancescoUniversity of Chieti, Italy
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Cicognani, AlesandroUniversity of Bologna, Italy
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Chiumello, GiuseppeVita-Salute University, Milan, Italy
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Cerutti, FrancoUniversity of Turin, Italy
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Zuccotti, Gian VincenzoUniversity of Milan, Italy
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Gomez Gila, Ana
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Rica, Itxaso
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Barrio, Raquel
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Clemente, Maria
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López Garcia, Maria José
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Rodriguez, Mercedes
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Gonzalez, Isabel
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Lopez, Juan Pedro
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Oyarzabal, Mirentxu
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Reeser, H M
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Nuboer, Roos
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Stouthart, Pauline
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Bratina, Natasa
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Bratanic, Nina
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de Kerdanet, Marc
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Weill, Jacques
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Ser, Nicole
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Barat, Pascal
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Bertrand, Anne Marie
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Carel, Jean-Claude
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Reynaud, Rachel
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Coutant, Regis
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Baron, Sabine
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Linköpings universitetPediatrik
(creator_code:org_t)
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Co-authors
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In:New England Journal of Medicine: Massachusetts Medical Society366:5, s. 433-4420028-47931533-4406
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Ludvigsson, John ...
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Krisky, David
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Casas, Rosaura
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Battelino, Tadej
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Castaño, Luis
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Greening, James
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Kordonouri, Olga
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Otonkoski, Timo
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Pozzilli, Paolo
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Robert, Jean-Jac ...
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Veeze, Henk J.
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Palmer, Jerry
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Samuelsson, Ulf
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Elding Larsson, ...
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Åman, Jan
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Kärdell, Gunilla
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Neiderud, Jan
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Lundström, Göran
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Albinsson, Eva
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Carlsson, Anneli ...
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Nordvall, Maria
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Fors, Hans
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Arvidsson, Carl- ...
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Edvardson, Stig
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Hanås, Ragnar
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Larsson, Karin
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Rathsman, Björn
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Forsgren, Henrik
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Desaix, Helena
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Forsander, Gun
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Nilsson, Nils-Ös ...
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Åkesson, Carl-Gö ...
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Keskinen, Päivi
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Veijola, Riitta
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Talvitie, Timo
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Raile, Klemens
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Kapellen, Thomas
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Burger, Walter
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Neu, Andreas
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Engelsberger, Il ...
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Heidtmann, Betti ...
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Bechtold, Suzann ...
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Leslie, David
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Chiarelli, Franc ...
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Cicognani, Alesa ...
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Chiumello, Giuse ...
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Cerutti, Franco
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Zuccotti, Gian V ...
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Gomez Gila, Ana
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Rica, Itxaso
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Barrio, Raquel
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Clemente, Maria
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López Garcia, Ma ...
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Rodriguez, Merce ...
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Gonzalez, Isabel
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Lopez, Juan Pedr ...
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Oyarzabal, Miren ...
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Reeser, H M
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Nuboer, Roos
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Stouthart, Pauli ...
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Bratina, Natasa
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Bratanic, Nina
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de Kerdanet, Mar ...
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Weill, Jacques
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Ser, Nicole
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Barat, Pascal
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Bertrand, Anne M ...
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Carel, Jean-Clau ...
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Reynaud, Rachel
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Coutant, Regis
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Baron, Sabine
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