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Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

Nguyet Pham, Minh (author)
University of Dusseldorf, Germany
Kolb, Hubert (author)
University of Dusseldorf, Germany
Mandrup-Poulsen, Thomas (author)
University of Copenhagen, Denmark
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Battelino, Tadej (author)
University of Childrens Hospital, Slovenia
Ludvigsson, Johnny (author)
Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
Pozzilli, Paolo (author)
University of Campus BioMed, Italy
Roden, Michael (author)
University of Dusseldorf, Germany
Schloot, Nanette C. (author)
University of Dusseldorf, Germany
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 (creator_code:org_t)
2013-02-05
2013
English.
In: Diabetes/Metabolism Research Reviews. - : John Wiley and Sons. - 1520-7552 .- 1520-7560. ; 29:2, s. 166-170
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background We investigated the adipokines adiponectin, leptin and resistin as serum biomarkers of beta-cell function in patients with type 1 diabetes. Methods One hundred and eighteen patients with type 1 diabetes (20.3 +/- 7.5years) diagnosed andlt;5years underwent standardized mixed meal test (MMTT) for 2h. Systemic concentrations of C-peptide, adiponectin, leptin and resistin obtained during MMTT were measured and compared between patient groups by multiple regression analysis. Results Patients were divided by their adipokine levels in subgroups above or below the median level (high versus low). High adiponectin levels (andgt;10.6 mu g/mL) were associated with lower C-peptide compared to the low adiponectin subgroup (pandlt;0.03). Increased leptin or resistin concentrations associated positively with beta-cell function even after adjustment for metabolic confounders (pandlt;0.04). The described associations between adipokines and C-peptide concentrations persisted in Spearman correlation tests (pandlt;0.05). Serum adipokines fell during MMTT (pandlt;0.05). Conclusions Serum adipokine levels differentially correlate with beta-cell function in type 1 diabetes independent of BMI or metabolic control. Serum adipokines should be investigated as biomarkers of beta-cell function in prospective studies and intervention trials in type 1 diabetes.

Keyword

adipokine
adiponectin
C-peptide
leptin
resistin
type 1 diabetes
MEDICINE
MEDICIN

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ref (subject category)
art (subject category)

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